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Perampanel
CAS No. 380917-97-5
Perampanel( E2007 | E 2007 )
Catalog No. M14317 CAS No. 380917-97-5
Perampanel (E2007) is a novel, orally active, noncompetitive AMPA receptor (AMPAR) antagonist with IC50 of 93 nM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
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Biological Information
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Product NamePerampanel
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NoteResearch use only, not for human use.
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Brief DescriptionPerampanel (E2007) is a novel, orally active, noncompetitive AMPA receptor (AMPAR) antagonist with IC50 of 93 nM.
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DescriptionPerampanel (E2007) is a novel, orally active, noncompetitive AMPA receptor (AMPAR) antagonist with IC50 of 93 nM; inhibits AMPA-induced increases in Ca2+(i) with minimal effect on NMDA-induced Ca2+(i); reduces seizure activity in rodent models of epilepsy.Epilepsy Approved.
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In Vitro——
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In Vivo——
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SynonymsE2007 | E 2007
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PathwayMembrane Transporter/Ion Channel
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TargetiGluR
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RecptoriGluR
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Research AreaNeurological Disease
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IndicationEpilepsy
Chemical Information
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CAS Number380917-97-5
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Formula Weight349.384
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Molecular FormulaC23H15N3O
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Purity>98% (HPLC)
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Solubility——
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SMILESO=C1C(C2=CC=CC=C2C#N)=CC(C3=NC=CC=C3)=CN1C4=CC=CC=C4
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Chemical Name2-(1',6'-dihydro-6'-oxo-1'-phenyl[2,3'-bipyridin]-5'-yl)-benzonitrile
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Hanada T, et al. Epilepsia. 2011 Jul;52(7):1331-40.
2. Ceolin L, et al. Neurochem Int. 2012 Sep;61(4):517-22.
3. Lees A, et al. Mov Disord. 2012 Feb;27(2):284-8.
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