SW-083688( SW083688 )

Catalog No. M14437 CAS No. 422281-45-6

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Datasheet

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Product Name

SW-083688
Note

Research use only, not for human use.
Brief Description

SW-083688 (SW083688) is a potent, highly selective TAOK2 (Thousand-And-One Kinase 2, MAP3K17) inhibitor with IC50 of 1.3 uM.
Description

SW-083688 (SW083688) is a potent, highly selective TAOK2 (Thousand-And-One Kinase 2, MAP3K17) inhibitor with IC50 of 1.3 uM; increases the abundance of p62 and inhibits autophagy; TAOK2 is an activator of p38 MAP kinase cascade that is up-regulated in response to environmental stresses, and a potential cancer therapeutic target.
In Vitro

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In Vivo

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Synonyms

SW083688
Pathway

MAPK/ERK Signaling
Target

MEK
Recptor

MEK
Research Area

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Indication

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CAS Number

422281-45-6
Formula Weight

455.529
Molecular Formula

C23H25N3O5S
Purity

>98% (HPLC)
Solubility

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SMILES

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Chemical Name

N-((2,3-dihydrobenzo[b][1,4]dioxin-2-yl)methyl)-3-(3-ethoxypropyl)-4-oxo-2-thioxo-1,2,3,4-tetrahydroquinazoline-7-carboxamide

1. Piala AT, et al. Bioorg Med Chem Lett. 2016 Aug 15;26(16):3923-7.

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