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EBI-1051
CAS No. 1801896-05-8
EBI-1051( EBI1051 )
Catalog No. M12747 CAS No. 1801896-05-8
EBI-1051 is a novel and orally efficacious MEK inhibitor with IC50 of 10.8 nM against MEK1.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 1413 | Get Quote |
|
| 50MG | 2862 | Get Quote |
|
| 100MG | 3870 | Get Quote |
|
| 200MG | Get Quote | Get Quote |
|
| 500MG | Get Quote | Get Quote |
|
| 1G | Get Quote | Get Quote |
|
Biological Information
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Product NameEBI-1051
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NoteResearch use only, not for human use.
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Brief DescriptionEBI-1051 is a novel and orally efficacious MEK inhibitor with IC50 of 10.8 nM against MEK1.
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DescriptionEBI-1051 is a novel and orally efficacious MEK inhibitor with IC50 of 10.8 nM against MEK1, inhibits viability of colo-205 cells with IC50 of 4.7 nM; shows superior potency in some cancer cell lines such as colon-205, A549 and MDA-MB-231 compared with AZD-6244.
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In Vitro——
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In Vivo——
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SynonymsEBI1051
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PathwayMAPK/ERK Signaling
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TargetMEK
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RecptorMEK
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Research Area——
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Indication——
Chemical Information
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CAS Number1801896-05-8
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Formula Weight504.228
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Molecular FormulaC18H15F2IN2O5
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Purity>98% (HPLC)
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Solubility——
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SMILESO=C(C1=C(NC2=CC=C(I)C=C2F)C(F)=C(OC=C3)C3=C1)NOC(CO)CO
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Chemical NameN-((1,3-Dihydroxypropan-2-yl)oxy)-7-fluoro-6-((2-fluoro-4-iodophenyl)amino)benzofuran-5-carboxamide
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Lu B, et al. Bioorg Med Chem. 2018 Feb 1;26(3):581-589.
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