Selonsertib( GS-4997 | GS4997 | GS 4997 )

Catalog No. M11920 CAS No. 1448428-04-3

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Product Name

Selonsertib
Note

Research use only, not for human use.
Brief Description

Selonsertib (GS-4997) is a highly selective and potent, ATP-competetive inhibitor of ASK1 (Apoptosis Signal-regulating Kinase 1, MAP3K5) with potential anti-inflammatory, antineoplastic and anti-fibrotic activities; orally bioavailable.
Description

Selonsertib (GS-4997) is a highly selective and potent, ATP-competetive inhibitor of ASK1 (Apoptosis Signal-regulating Kinase 1, MAP3K5) with potential anti-inflammatory, antineoplastic and anti-fibrotic activities; orally bioavailable. Steatohepatitis,Phase 3 Clinical(In Vitro):Selonsertib (GS-4997) is a clinical stage ASK1 inhibitor, which has been evaluated as an experimental treatment for diabetic nephropathy and kidney fibrosis. Selonsertib (GS-4997) is a highly selective and potent once-daily oral ASK1 inhibitor that competes with ATP in the ASK1 catalytic kinase domain.
In Vitro

Selonsertib (GS-4997) is a clinical stage ASK1 inhibitor, which has been evaluated as an experimental treatment for diabetic nephropathy and kidney fibrosis. Selonsertib (GS-4997) is a highly selective and potent once-daily oral ASK1 inhibitor that competes with ATP in the ASK1 catalytic kinase domain.
In Vivo

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Synonyms

GS-4997 | GS4997 | GS 4997
Pathway

MAPK/ERK Signaling
Target

MEK
Recptor

ASK1
Research Area

Other Indications
Indication

Steatohepatitis

CAS Number

1448428-04-3
Formula Weight

445.4921
Molecular Formula

C24H24FN7O
Purity

>98% (HPLC)
Solubility

DMSO: ≥ 31 mg/mL
SMILES

CC1=CC(=C(C=C1N2C=C(N=C2)C3CC3)C(=O)NC4=CC=CC(=N4)C5=NN=CN5C(C)C)F
Chemical Name

Benzamide, 5-(4-cyclopropyl-1H-imidazol-1-yl)-2-fluoro-4-methyl-N-[6-[4-(1-methylethyl)-4H-1,2,4-triazol-3-yl]-2-pyridinyl]-

1. Lin JH, et al. Nephron. 2015;129(1):29-33.

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