Pomaglumetad methionil hydrochloride( —— )

Catalog No. M35610 CAS No. 635318-26-2

Pomaglumetad methionine hydrochloride (LY2140023 hydrochloride) is a methionine prodrug of LY404039 with oral activity.

Purity : >98% (HPLC)

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HPLC

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Biological Information

Product Name

Pomaglumetad methionil hydrochloride
Note

Research use only, not for human use.
Brief Description

Pomaglumetad methionine hydrochloride (LY2140023 hydrochloride) is a methionine prodrug of LY404039 with oral activity.
Description

Pomaglumetad methionil hydrochloride (LY2140023 hydrochloride) is an orally active, methionine prodrug of the selective mGlu2/3 receptor agonist LY404039. Pomaglumetad methionil hydrochloride has the potential for schizophrenia research.
In Vitro

Pomaglumetad methionil (LY2140023) is a high-affinity peptide transporter 1 (PEPT1) substrate with a Km value of ~30 μM.LY2140023 is active against [14C]Gly-Sar with an IC50 value of 0.018 mM.
In Vivo

Pomaglumetad methionil (LY2140023; orally; 3-300 mg/kg; once daily for 7 days) dose-dependent increases the levels of the dopamine metabolites dihydroxyphenylacetic acid (DOPAC) and homovanillic acid (HVA) .Animal Model:Male Fischer rats (approximately 250 g) Dosage:3 mg/kg, 10 mg/kg, and 300 mg/kg Administration:Orally; once daily for 7 days Result:Dose-dependent increased the levels of the dopamine metabolites DOPAC and HVA.
Synonyms

——
Pathway

Neuroscience
Target

GluR
Recptor

GluR
Research Area

——
Indication

——

Chemical Information

CAS Number

635318-26-2
Formula Weight

402.87
Molecular Formula

C12H19ClN2O7S2
Purity

>98% (HPLC)
Solubility

In Vitro:?DMSO : 25 mg/mL (62.05 mM; Ultrasonic )
SMILES

Cl.[H][C@@]12[C@@H](C(O)=O)[C@]1([H])S(=O)(=O)C[C@@]2(NC(=O)[C@@H](N)CCSC)C(O)=O
Chemical Name

——

Shipping & Storage Information

Storage

(-20℃)
Shipping

With Ice Pack
Stability

≥ 2 years

Reference

1. Lowe S, et al. Effects of a novel mGlu?/? receptor agonist prodrug, LY2140023 monohydrate, on central monoamine turnover as determined in human and rat cerebrospinal fluid. Psychopharmacology (Berl). 2012 Feb;219(4):959-70.?

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