Penciclovir( VSA-671 | BRL-39123 )

Catalog No. M14368 CAS No. 39809-25-1

A guanosine analogue antiviral agent used for the treatment of various herpesvirus (HSV) infections.

Purity : >98% (HPLC)

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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Biological Information

Product Name

Penciclovir
Note

Research use only, not for human use.
Brief Description

A guanosine analogue antiviral agent used for the treatment of various herpesvirus (HSV) infections.
Description

A guanosine analogue antiviral agent used for the treatment of various herpesvirus (HSV) infections; inhibits viral DNA polymerase and exhibits low toxicity and good selectivity.HSV Infection Approved(In Vitro):Penciclovir (0-100 μg/ml) shows anti-herpesvirus activity with EC50s of 0.5, 0.8, 2.4, 52, 100, 1.2, 1.6, 0.9, >100 μg/ml for HSV-1 (HFEM), HSV-2 (MS), VZV (Ellen), CMV (AD-169), BHV-1 (Oxford 1964), BHV-2 (New York 1), EHV-1(Quai Hals), FHV-1 (B927), SVV, respectively.Penciclovir (0-100 μg/ml) shows no-toxic to uninfected human cells.(In Vivo):Penciclovir (100 mg/kg; s.c.; daily for 5 days) preventes mortality in mouse.
In Vitro

Penciclovir (0-100 μg/ml) shows anti-herpesvirus activity with EC50s of 0.5, 0.8, 2.4, 52, 100, 1.2, 1.6, 0.9, >100 μg/ml for HSV-1 (HFEM), HSV-2 (MS), VZV (Ellen), CMV (AD-169), BHV-1 (Oxford 1964), BHV-2 (New York 1), EHV-1(Quai Hals), FHV-1 (B927), SVV, respectively.Penciclovir (0-100 μg/ml) shows no-toxic to uninfected human cells. Cell Cytotoxicity AssayCell Line:MRC-5,WISH, Flow 4000, Flow 12000, RPMI 2650, WI-38, WI-38 VA13, Hs68, HEp-2, RD, SCC-13,Primary cells Concentration:0-100 μg/ml Incubation Time:Result:Showed no-toxic with IC50s of >100, >100, 100, >100, 60, >100, >100, >100, >100, >100, >100, >100 for MRC-5,WISH, Flow 4000, Flow 12000, RPMI 2650, WI-38, WI-38 VA13, Hs68, HEp-2, RD, SCC-13,Primary cells, respectively.
In Vivo

Penciclovir (100 mg/kg; s.c.; daily for 5 days) preventes mortality in mouse. Animal Model:Three-week-old female Balb/c mice Dosage:100 mg/kg Administration:S.c.; daily for 5 days Result:Reduced virus titres in the respiratory organs of both w/t- and PR3-infected mice.
Synonyms

VSA-671 | BRL-39123
Pathway

Microbiology/Virology
Target

HSV
Recptor

EBV|HCMV|HSV-1|HSV-2|VZV
Research Area

Infection
Indication

HSV Infection

Chemical Information

CAS Number

39809-25-1
Formula Weight

253.2578
Molecular Formula

C10H15N5O3
Purity

>98% (HPLC)
Solubility

DMSO: ≥ 53 mg/mL
SMILES

C1=NC2=C(N1CCC(CO)CO)NC(=NC2=O)N
Chemical Name

6H-Purin-6-one, 2-amino-1,9-dihydro-9-[4-hydroxy-3-(hydroxymethyl)butyl]-