AZ 3146( AZ3146 | AZ 3146 | AZ-3146 )

Catalog No. M17147 CAS No. 1124329-14-1

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

AZ 3146
Note

Research use only, not for human use.
Brief Description

AZ3146 is a selective Mps1 inhibitor with IC50 of ~35 nM.
Description

AZ3146 is a novel and potent Mps1 inhibitor, which was used to probe the role of Mps1's catalytic activity during mitosis. AZ3146 also inhibits FAK, JNK1, JNK2, KSP and Kit. In in vitro kinase assays, AZ3146 inhibited human Mps1Cat with an IC50 (50% inhibitory concentration) of ~35 nM. AZ3146 also efficiently inhibited autophosphorylation of full-length Mps1 immunoprecipitated from human cells.
In Vitro

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In Vivo

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Synonyms

AZ3146 | AZ 3146 | AZ-3146
Pathway

Microbiology/Virology
Target

HSV
Recptor

Mps1
Research Area

Cancer
Indication

——

CAS Number

1124329-14-1
Formula Weight

452.55
Molecular Formula

C24H32N6O3
Purity

>98% (HPLC)
Solubility

DMSO : 11.75 mg/mL 25.96 mM;
SMILES

COc1c(Nc2ncc3n(C)c(=O)n(C4CCCC4)c3n2)ccc(OC2CCN(C)CC2)c1
Chemical Name

9-cyclopentyl-2-(2-methoxy-4-(1-methylpiperidin-4-yloxy)phenylamino)-7-methyl-7H-purin-8(9H)-one

1. Hewitt L, et al. J Cell Biol, 2010, 190(1), 25-34.

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