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POMHEX
CAS No. 2004714-34-3
POMHEX( —— )
Catalog No. M34848 CAS No. 2004714-34-3
Pomhex, a cell-permeable potent enolase inhibitor with anticancer activity, is used in the study of cancer lethality.Pomhex, a racemic mixture, is a potent and selective ENO2 inhibitor.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 225 | Get Quote |
|
| 5MG | 345 | Get Quote |
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| 10MG | 512 | Get Quote |
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| 25MG | 803 | Get Quote |
|
| 50MG | 1086 | Get Quote |
|
| 100MG | 1458 | Get Quote |
|
| 500MG | Get Quote | Get Quote |
|
| 1G | Get Quote | Get Quote |
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Biological Information
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Product NamePOMHEX
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NoteResearch use only, not for human use.
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Brief DescriptionPomhex, a cell-permeable potent enolase inhibitor with anticancer activity, is used in the study of cancer lethality.Pomhex, a racemic mixture, is a potent and selective ENO2 inhibitor.
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DescriptionPOMHEX, a racemic mixture and a cell-permeable pivaloyloxymethyl (POM) proagent of HEX, is a potent, ENO2-specific inhibitor of enolase. POMHEX exhibits low-nanomolar potency against ENO1-deleted cells in vitro and is capable of eradicating ENO1-deleted xenografted tumours in vivo. POMHEX is a potent glycolysis inhibitor.
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In VitroCell Proliferation Assay Cell Line:ENO1-deleted (D423, red), ENO1-isogenically rescued (D423 ENO1, blue) and ENO1-WT (LN319, grey) cells.Concentration:78 nM.Incubation Time:8 h.Result:Down-regulated cell density.
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In Vivo——
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Synonyms——
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PathwayCytoskeleton/Cell Adhesion Molecules
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TargetGlucokinase
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RecptorGlucokinase
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Research Area——
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Indication——
Chemical Information
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CAS Number2004714-34-3
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Formula Weight423.4
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Molecular FormulaC17H30NO9P
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 100 mg/mL (236.18 mM; Ultrasonic )
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SMILESO=C(OCOP(=O)(OCOC(=O)C(C)(C)C)C1C(=O)N(O)CCC1)C(C)(C)C
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Yu-Hsi Lin, et al. An enolase inhibitor for the targeted treatment of ENO1-deleted cancers. Nat Metab. 2020 Nov 23.?
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