Hexestrol

Research use only, not for human use.

Hexestrol binds to ERα and ERβ with EC50 of 0.07 nM and 0.175 nM, respectively.

Hexestrol is a synthetic ER agonist, microtubule polymerization inhibitor, and potential carcinogen. It induces mitotic arrest, aneuploidy, and DNA adduct formation.(In Vivo):Hexestrol (3 and 6 mg/kg; i.p. once daily for 30 days) has a not significant influence in the ovaries from mice at the dose of 3 mg/kg.

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Hexestrol (3 and 6 mg/kg; i.p. once daily for 30 days) has a not significant influence in the ovaries from mice at the dose of 3 mg/kg. Animal Model:Mus musculus (90-120 days, 25-50 g)Dosage:3, 6 mg/kg (adopted the same dose used to increase weight gain in cattle)Administration:I.p. once daily for 30 days Result:Numerous follicles in different stages of development were found at the dose of 3 mg/kg in the ovaries.Not detected the corpora lutea (CL) at the dose of 6 mg/kg.

Cycloestrol | Erythrohexestrol | Hexoestrol | HSDB 2149

Cytoskeleton/Cell Adhesion Molecules

Glucokinase

ERα| ERβ

Endocrinology

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84-16-2

270.37

C18H22O2

>98% (HPLC)

In Vitro:?DMSO : 100 mg/mL (369.86 mM)

CC[C@@H]([C@@H](CC)C1=CC=C(O)C=C1)C1=CC=C(O)C=C1

4,4'-((3R,4S)-hexane-3,4-diyl)diphenol

(-20℃)

With Ice Pack

≥ 2 years