Fluticasone furoate

Research use only, not for human use.

Fluticasone furoate is a synthetic trifluorinated corticosteroid derived from fluticasone with a Kd of 0.3 nM.

Fluticasone furoate is a synthetic trifluorinated corticosteroid derived from fluticasone with a Kd of 0.3 nM. Fluticasone furoate has potent anti-inflammatory, anti-asthmatic activity, and low systemic exposure. Fluticasone furoate can be used as a nasal spray for studies about allergic rhinitis treatment.(In Vitro):Fluticasone furoate displays great potency in inhibiting tumor necrosis factor synthesis and action. Fluticasone furoate prevents damage to cultured human lung epithelial cells by different stimuli.(In Vivo):Fluticasone furonate is excreted mainly in the feces, with only minor amounts in the urine. Fluticasone furonate is 99.4% bound to plasma protein in vitro. Clearance of Fluticasone furonate is primarily by hydrolysis in the liver by the cytochrome P450 isozyme CYP3A4 that converts the drug to the 17β-carboxylic acid metabolite, which displays low glucocorticoid receptor agonist potency.

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Fluticasone furoate | Avamys | Veramyst | Allermist

Cytoskeleton/Cell Adhesion Molecules

Glucokinase

Toll-like Receptor (TLR)

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397864-44-7

538.58

C27H29F3O6S

>98% (HPLC)

In Vitro:?DMSO : 100 mg/mL (185.67 mM)

C[C@@H]1C[C@H]2[C@@H]3C[C@H](F)C4=CC(=O)C=C[C@]4(C)[C@@]3(F)[C@@H](O)C[C@]2(C)[C@@]1(OC(=O)c1ccco1)C(=O)SCF

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(-20℃)

With Ice Pack

≥ 2 years