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PNU-74654
CAS No. 113906-27-7
PNU-74654( PNU74654 | PNU 74654 )
Catalog No. M10489 CAS No. 113906-27-7
A novel potent Wnt/beta-catenin inhibitor by disrupting Tcf/β-catenin interaction; binds to β-catenin with Kd of 450 nM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 46 | In Stock |
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| 10MG | 65 | In Stock |
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| 25MG | 138 | In Stock |
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| 50MG | 257 | In Stock |
|
| 100MG | 464 | In Stock |
|
| 200MG | 672 | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NamePNU-74654
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NoteResearch use only, not for human use.
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Brief DescriptionA novel potent Wnt/beta-catenin inhibitor by disrupting Tcf/β-catenin interaction; binds to β-catenin with Kd of 450 nM.
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DescriptionA novel potent Wnt/beta-catenin inhibitor by disrupting Tcf/β-catenin interaction; binds to β-catenin with Kd of 450 nM, significantly decreases NCI-H295 cell proliferation (96 h, IC50=69 nM), increases early and late apoptosis, decreases nuclear beta-catenin accumulation, impaires CTNNB1/beta-catenin expression and increases beta-catenin target genes.
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In Vitro——
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In Vivo——
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SynonymsPNU74654 | PNU 74654
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PathwayWnt/Notch/Hedgehog
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TargetBeta-catenin
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RecptorBeta-catenin
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Research AreaCancer
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Indication——
Chemical Information
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CAS Number113906-27-7
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Formula Weight320.34194
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Molecular FormulaC19H16N2O3
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Purity>98% (HPLC)
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SolubilityDMSO: ≥ 30 mg/mL
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SMILESO=C(N/N=C/C1=CC=C(C)O1)C2=CC=CC=C2OC3=CC=CC=C3
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Chemical NameBenzoic acid, 2-phenoxy-, 2-[(5-methyl-2-furanyl)methylene]hydrazide
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Leal LF, et al. Oncotarget. 2015 Dec 15;6(40):43016-32.
2. Trosset JY, et al. Proteins. 2006 Jul 1;64(1):60-7.
3. Wang H, et al. Inflamm Res. 2016 Jan;65(1):61-9.
molnova catalog
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