UU-T02( UU-T 02 )

Catalog No. M12086 CAS No. 1500080-17-0

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

UU-T02
Note

Research use only, not for human use.
Brief Description

UU-T02 is a novel potent, selective small-molecule inhibitor of β-catenin/Tcf4 interaction with Ki of 1.36 uM.
Description

UU-T02 is a novel potent, selective small-molecule inhibitor of β-catenin/Tcf4 interaction with Ki of 1.36 uM; displays 63-fold and 175-fold selectivity over β-catenin/E-cadherin and β-catenin/APC interactions, respectively.
In Vitro

UU-T02 displays Ki values of 1.4 μM and 1.3 μM for β-catenin/Tcf PPI in FP assay and in AlphaScreen assay, respectively.UU-T02 inhibits β-catenin/Tcf4, β-catenin/E-cadherin, β-catenin/APC-R3, with the IC50 of 6.3, 680, 210 μM，respectively.
In Vivo

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Synonyms

UU-T 02
Pathway

Wnt/Notch/Hedgehog
Target

Beta-catenin
Recptor

Beta-catenin
Research Area

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Indication

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CAS Number

1500080-17-0
Formula Weight

665.096
Molecular Formula

C33H33ClN4O9
Purity

>98% (HPLC)
Solubility

——
SMILES

O=C(O)CC[C@H](NC([C@@H](NC([C@@H](NC(CC(N1)=CC2=C1C=CC(Cl)=C2)=O)CC3=CC=C4C=CC=CC4=C3)=O)CC(O)=O)=O)C(OC)=O
Chemical Name

(S)-4-((S)-3-carboxy-2-((S)-2-(2-(5-chloro-1H-indol-2-yl)acetamido)-3-(naphthalen-2-yl)propanamido)propanamido)-5-methoxy-5-oxopentanoic acid

1. Huang Z, et al. ACS Chem Biol. 2014 Jan 17;9(1):193-201.

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