UU-T03( UU-T 03 )

Catalog No. M12263 CAS No. 1586007-00-2

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Datasheet

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Product Name

UU-T03
Note

Research use only, not for human use.
Brief Description

UU-T03 is the ethyl ester derivative of UU-T02, which is a potent, selective inhibitor of β-catenin/Tcf4 interaction with Ki of 1.36 uM.
Description

UU-T03 is the ethyl ester derivative of UU-T02, which is a potent, selective inhibitor of β-catenin/Tcf4 interaction with Ki of 1.36 uM; exhibits growth inhibition of SW480 cells with IC50 of 10.77 uM; downregulates the transcription of AXIN2, LGR5, cyclin D1, and c-Myc in dose-dependent manners in SW480 cells.
In Vitro

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In Vivo

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Synonyms

UU-T 03
Pathway

Wnt/Notch/Hedgehog
Target

Beta-catenin
Recptor

Beta-catenin
Research Area

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Indication

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CAS Number

1586007-00-2
Formula Weight

721.204
Molecular Formula

C37H41ClN4O9
Purity

>98% (HPLC)
Solubility

——
SMILES

O=C(OCC)CC[C@@H](C(OC)=O)NC([C@@H](NC([C@@H](NC(CC(N1)=CC2=C1C=CC(Cl)=C2)=O)CC3=CC=C4C=CC=CC4=C3)=O)CC(OCC)=O)=O
Chemical Name

5-ethyl 1-methyl ((S)-2-((S)-2-(2-(5-chloro-1H-indol-2-yl)acetamido)-3-(naphthalen-2-yl)propanamido)-4-ethoxy-4-oxobutanoyl)-L-glutamate

1. Huang Z, et al. ACS Chem Biol. 2014 Jan 17;9(1):193-201.

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