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PD173952
CAS No. 305820-75-1
PD173952( —— )
Catalog No. M34013 CAS No. 305820-75-1
PD173952 is a tyrosine (Src) kinase and Myt1 inhibitor with antitumor activity, inhibits Lyn, Abl and Csk, and induces Bcr-Abl-dependent hematopoietic cell apoptosis.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 149 | Get Quote |
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| 5MG | 244 | Get Quote |
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| 10MG | 363 | Get Quote |
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| 25MG | 578 | Get Quote |
|
| 50MG | 817 | Get Quote |
|
| 500MG | Get Quote | Get Quote |
|
| 1G | Get Quote | Get Quote |
|
Biological Information
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Product NamePD173952
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NoteResearch use only, not for human use.
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Brief DescriptionPD173952 is a tyrosine (Src) kinase and Myt1 inhibitor with antitumor activity, inhibits Lyn, Abl and Csk, and induces Bcr-Abl-dependent hematopoietic cell apoptosis.
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DescriptionPD173952 is a tyrosine kinases inhibitor with IC50s of 0.3, 1.7 and 6.6 nM against Lyn, Abl and Csk, respectively. PD173952 is also a potent Myt1 kinase inhibitor with a Ki of 8.1 nM. PD173952 induces apoptosis.
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In VitroWestern Blot Analysis Cell Line:K562 cells Concentration:0, 25, 50, 100, 200, 500 and 1000 nM Incubation Time:12 h Result:Inhibited tyrosine phosphorylation of p210Bcr-Abl and CrkL.Cell Viability Assay Cell Line:K562 cells Concentration:0.5 μM Incubation Time:1-4 days Result:Caused cell death in a time-dependent manner.Western Blot Analysis Cell Line:K562 and MEG-01 cells Concentration:0.5 μM Incubation Time:24 and 48 h Result:85-kDa PARP fragment was detected.
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In Vivo——
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Synonyms——
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PathwayAngiogenesis
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TargetSrc
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RecptorSrc | Wee1
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Research Area——
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Indication——
Chemical Information
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CAS Number305820-75-1
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Formula Weight482.36
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Molecular FormulaC24H21Cl2N5O2
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Purity>98% (HPLC)
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Solubility——
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SMILESO=C1C(=CC=2C=NC(=NC2N1C)NC3=CC=C(C=C3)N4CCOCC4)C5=C(Cl)C=CC=C5Cl
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Dorsey JF, et al. Interleukin-3 protects Bcr-Abl-transformed hematopoietic progenitor cells from apoptosis induced by Bcr-Abl tyrosine kinase inhibitors. Leukemia. 2002 Sep;16(9):1589-95.?
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