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Nampt activator-2

CAS No. 2237268-90-3

Nampt activator-2( —— )

Catalog No. M36469 CAS No. 2237268-90-3

Nampt activator-2 is a NAMPT activator (EC50: 0.023 μM). Nampt activator-2 has an affinity for CYP2C9, 2D6, and 2C19 with affinity values of 0.060 μM, 0.41 μM, and 0.59 μM, respectively.

Purity : >98% (HPLC)

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Biological Information

  • Product Name
    Nampt activator-2
  • Note
    Research use only, not for human use.
  • Brief Description
    Nampt activator-2 is a NAMPT activator (EC50: 0.023 μM). Nampt activator-2 has an affinity for CYP2C9, 2D6, and 2C19 with affinity values of 0.060 μM, 0.41 μM, and 0.59 μM, respectively.
  • Description
    Nampt activator-2 (compound 34) is a potent NAMPT activator, with EC50 of 0.023 μM. Nampt activator-2 shows moderate activity against CYP2C9 (0.060 μM), 2D6 (0.41 μM) and 2C19 (0.59 μM).
  • In Vitro
    ——
  • In Vivo
    Animal Model:Mouse Dosage:1 mg/kg iv and 10 mg/kg po Administration:IV, PO; once (Pharmacokinetic Analysis)Result:Pharmacokinetic Parameters of Nampt activator-2 in mouse.
  • Synonyms
    ——
  • Pathway
    Metabolic Enzyme/Protease
  • Target
    NAMPT
  • Recptor
    NAMPT | P450
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    2237268-90-3
  • Formula Weight
    390.84
  • Molecular Formula
    C17H15ClN4O3S
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 250 mg/mL (639.65 mM; Ultrasonic )
  • SMILES
    S(=O)(=O)(C1=CC=C(NC(NCC=2C=NNC2)=O)C=C1)C3=CC=C(Cl)C=C3
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Pinkerton AB, et al. Optimization of a urea-containing series of nicotinamide phosphoribosyltransferase (NAMPT) activators. Bioorg Med Chem Lett. 2021 Jun 1;41:128007. ?
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