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NSC622608

CAS No. 2593254-90-9

NSC622608( —— )

Catalog No. M28030 CAS No. 2593254-90-9

NSC622608 is a small-molecule ligand for V-domain Ig suppressor of T-cell activation (VISTA) which is an immune checkpoint that affects the ability of T-cells to attack tumors.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    NSC622608
  • Note
    Research use only, not for human use.
  • Brief Description
    NSC622608 is a small-molecule ligand for V-domain Ig suppressor of T-cell activation (VISTA) which is an immune checkpoint that affects the ability of T-cells to attack tumors.
  • Description
    NSC622608 is a small-molecule ligand for V-domain Ig suppressor of T-cell activation (VISTA) which is an immune checkpoint that affects the ability of T-cells to attack tumors.(In Vitro):NSC622608 blocked VISTA signaling in vitro, enhanced T-cell proliferation, and restored T-cell activation in the presence of VISTA-expressing cancer cell lines.
  • In Vitro
    NSC622608 disrupts VISTA-VSIG-3 interaction with an IC50 value of 9.7 ± 0.3 μM.
  • In Vivo
    ——
  • Synonyms
    ——
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    Antifection|MMP|Leishmania tropica
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    2593254-90-9
  • Formula Weight
    322.24
  • Molecular Formula
    C9H12BrN3OS2
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 41.67 mg/mL (129.31 mM)
  • SMILES
    CN(C)C(SS1)=NC1=NCC2=CC=CO2.[H]Br
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Olaf Kunert, et al. Antiplasmodial and leishmanicidal activity of biflavonoids from Indian Selaginella bryopteris. Phytochemistry Letters,2008,1(4):171-4.
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