NC-005( NC 005 | NC005 )

Catalog No. M10955 CAS No. 1237540-74-7

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

Get Quotation Bulk Inquiry Add to Cart

Product Name

NC-005
Note

Research use only, not for human use.
Brief Description

A potent, specific immunoproteasome β5 subunit inhibitor with IC50 of 44 nM, 105 and 225-fold selectivity over β2i and β1i subunit, respecitvely.
Description

A potent, specific immunoproteasome β5 subunit inhibitor with IC50 of 44 nM, 105 and 225-fold selectivity over β2i and β1i subunit, respecitvely; shows cytotoxicity against multiple myeloma cells with IC50 of 30 nM-1.5 uM.
In Vitro

——
In Vivo

——
Synonyms

NC 005 | NC005
Pathway

Proteasome/Ubiquitin
Target

Proteasome
Recptor

Proteasome
Research Area

——
Indication

——

CAS Number

1237540-74-7
Formula Weight

663.815
Molecular Formula

C40H45N3O6
Purity

>98% (HPLC)
Solubility

——
SMILES

——
Chemical Name

(S)-3-(4-methoxyphenyl)-N-((S)-1-(((S)-4-methyl-1-((R)-2-methyloxiran-2-yl)-1-oxopentan-2-yl)amino)-1-oxo-3-phenylpropan-2-yl)-2-(2-(naphthalen-2-yl)acetamido)propanamide

1. Britton M, et al. Chem Biol. 2009 Dec 24;16(12):1278-89. 2. de Bruin G, et al. J Med Chem. 2014 Jul 24;57(14):6197-209.

Calculator

molnova catalog