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Proteasome inhibitor IX

CAS No. 856849-35-9

Proteasome inhibitor IX( PS-IX | AM114 )

Catalog No. M27475 CAS No. 856849-35-9

AM 114 is an inhibitor of chymotrypsin-like activity of the 20S proteasome (IC50 ~1 μM).

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
1 mL x 10 mM in DMSO 30 In Stock
10MG 32 In Stock
25MG 65 In Stock
50MG 112 In Stock
100MG 187 In Stock
200MG Get Quote In Stock
500MG 448 In Stock
1G Get Quote In Stock
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Biological Information

  • Product Name
    Proteasome inhibitor IX
  • Note
    Research use only, not for human use.
  • Brief Description
    AM 114 is an inhibitor of chymotrypsin-like activity of the 20S proteasome (IC50 ~1 μM).
  • Description
    AM 114 is an inhibitor of chymotrypsin-like activity of the 20S proteasome (IC50 ~1 μM). AM 114 shows potent anticancer activity. AM 114 exhibits HCT116 p53+/+ cells growth inhibitory activity(IC50 = 1.49 μM).(In Vitro):AM114 exhibits potent activity against p53+/+ cells in colony formation assay, with an IC50 value of 0.6 μM. AM114 treatment inhibits the chymotrypsin-like activity of the 20S proteasome in vitro, leading to a significant accumulation of ubiquitinated p53 and other cellular proteins in whole cells. In HCT116 p53+/+ cells, AM114(0.1-10 μM) treatment causes a loss of cell survival in the p53+/+ and p53-/- cells by approximately 70 and 20%, respectively at a concentration of 1 μM.
  • In Vitro
    Proteasome inhibitor IX (AM114; 0.1-10 μM; 14 days; HCT116 p53+/+ cells) treatment causes a loss of cell survival in the p53+/+ and p53-/- cells by approximately 70 and 20%, respectively at a concentration of 1 μM. Proteasome inhibitor IX (AM114) exhibits potent activity against p53+/+ cells in colony formation assay, with an IC50 value of 0.6 μM. Incubation of HCT116 p53+/+ cells with 1 μM Proteasome inhibitor IX (AM114) causes 28% of the cells to exhibit positive Annexin V staining at 48 h, and this fraction of dead cells increased to 76% at 72 h.Proteasome inhibitor IX (AM114) treatment inhibits the chymotrypsin-like activity of the 20S proteasome in vitro, leading to a significant accumulation of ubiquitinated p53 and other cellular proteins in whole cells.
  • In Vivo
    ——
  • Synonyms
    PS-IX | AM114
  • Pathway
    Proteasome/Ubiquitin
  • Target
    Proteasome
  • Recptor
    CRAC channel
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    856849-35-9
  • Formula Weight
    377.01
  • Molecular Formula
    C20H21B2NO5
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 6.25 mg/mL (16.58 mM)
  • SMILES
    O=C(/C(CN(C)C/1)=C\C2=CC=C(B(O)O)C=C2)C1=C/C3=CC=C(B(O)O)C=C3
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Lanotte A, Mazzino A. Anisotropic nonperturbative zero modes for passively advected magnetic fields. Phys Rev E Stat Phys Plasmas Fluids Relat Interdiscip Topics. 1999 Oct;60(4 Pt A):R3483-6.
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