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Home - Products - Proteasome/Ubiquitin - Proteasome - (1S,2S)-Bortezomib

(1S,2S)-Bortezomib

CAS No. 1132709-14-8

(1S,2S)-Bortezomib( Bortezomib )

Catalog No. M26020 CAS No. 1132709-14-8

(1S,2S)-Bortezomib is an enantiomer of Bortezomib. Bortezomib is a reversible and selective inhibitor of the proteasome with a Ki of 0.6 nM for 20S proteasome.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    (1S,2S)-Bortezomib
  • Note
    Research use only, not for human use.
  • Brief Description
    (1S,2S)-Bortezomib is an enantiomer of Bortezomib. Bortezomib is a reversible and selective inhibitor of the proteasome with a Ki of 0.6 nM for 20S proteasome.
  • Description
    (1S,2S)-Bortezomib is an enantiomer of Bortezomib. Bortezomib is a reversible and selective inhibitor of the proteasome with a Ki of 0.6 nM for 20S proteasome.(In Vitro):Bortezomib disrupts the cell cycle, induces apoptosis, inhibits NF-κB, and possesses anti-cancer capacity.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    Bortezomib
  • Pathway
    Proteasome/Ubiquitin
  • Target
    Proteasome
  • Recptor
    Non-cleavable
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    1132709-14-8
  • Formula Weight
    384.24
  • Molecular Formula
    C19H25BN4O4
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 50 mg/mL (130.13 mM)
  • SMILES
    [C@H](CC1=CC=CC=C1)(C(N[C@H](CC(C)C)B(O)O)=O)NC(=O)C=2C=NC=CN2
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Pyrrolobenzodiazepine Dimer Antibody-Drug Conjugates: Synthesis and Evaluation of Noncleavable Drug-Linkers. J Med Chem. 2017 Dec 14;60(23):9490-9507.
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