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MG-101
CAS No. 110044-82-1
MG-101( Calpain inhibitor I | ALLN )
Catalog No. M10384 CAS No. 110044-82-1
A potent inhibitor of cysteine proteases including calpain I (Ki= 190 nM), calpain II (Ki= 220 nM), cathepsin B (Ki= 150 nM) and cathepsin L (Ki= 500 pM).
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 43 | In Stock |
|
| 10MG | 67 | In Stock |
|
| 25MG | 141 | In Stock |
|
| 50MG | 224 | In Stock |
|
| 100MG | 357 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameMG-101
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NoteResearch use only, not for human use.
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Brief DescriptionA potent inhibitor of cysteine proteases including calpain I (Ki= 190 nM), calpain II (Ki= 220 nM), cathepsin B (Ki= 150 nM) and cathepsin L (Ki= 500 pM).
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DescriptionA potent inhibitor of cysteine proteases including calpain I (Ki= 190 nM), calpain II (Ki= 220 nM), cathepsin B (Ki= 150 nM) and cathepsin L (Ki= 500 pM); activates p53-dependent apoptosis in tumor cell lines; increases activated p53, p21 and caspase levels and promotes cell cycle arrest through inhibition of cyclin D degradation in vitro.
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In Vitro——
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In VivoAnimal Model:Female athymic nude mice with HCT116 cells injectionDosage:10 mg/kg Administration:Intraperitoneal injection; 10 mg/kg once daily; for 15 days Result:Significantly decreased tumor weight and volume of treated mice at day 26 compared to control mice, and showed no effect on body weights.
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SynonymsCalpain inhibitor I | ALLN
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PathwayProteasome/Ubiquitin
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TargetProteasome
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RecptorProteasome
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Research AreaOther Indications
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Indication——
Chemical Information
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CAS Number110044-82-1
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Formula Weight383.5255
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Molecular FormulaC20H37N3O4
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Purity>98% (HPLC)
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Solubility10 mM in DMSO
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SMILESCC(C)C[C@H](NC(C)=O)C(N[C@@H](CC(C)C)C(N[C@H](CCCC)C=O)=O)=O
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Chemical NameL-Leucinamide, N-acetyl-L-leucyl-N-[(1S)-1-formylpentyl]-
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Zhang L, et al. J Biol Chem. 1999 Mar 26;274(13):8966-72.
2. Inoue S,et al. J Biol Chem. 1991 Jul 15;266(20):13311-7.
3. Sherwood SW, et al. Proc Natl Acad Sci U S A. 1993 Apr 15;90(8):3353-7.
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