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O-phenanthroline
CAS No. 66-71-7
O-phenanthroline( 1,10-phenanthroline | Ortho-phenanthroline | OPA )
Catalog No. M15547 CAS No. 66-71-7
A selective inhibitor of 26S proteasome subunit Rpn11 with IC50 of 10±2 uM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 100MG | 41 | In Stock |
|
| 200MG | Get Quote | In Stock |
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| 500MG | Get Quote | In Stock |
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| 1G | Get Quote | In Stock |
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Biological Information
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Product NameO-phenanthroline
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NoteResearch use only, not for human use.
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Brief DescriptionA selective inhibitor of 26S proteasome subunit Rpn11 with IC50 of 10±2 uM.
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DescriptionA selective inhibitor of 26S proteasome subunit Rpn11 with IC50 of 10±2 uM; shows no activity for other DUBs (USP1/USP2/USP4/USP5/USP7/USP8/USP20/UCH37, IC50>50 uM); blocks cellular proteasome function, induces apoptosis in MM cells and overcomes resistance to proteasome inhibitor bortezomib, activates caspase cascade and endoplasmic stress response signaling; reduces progression of tumor growth and prolongs survival in mice MM xenograft model.(In Vitro):o-Phenanthroline (1,10-Phenanthroline, 1mM) inhibits autolysis of sea cucumber body wall.
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In Vitroo-Phenanthroline (1,10-Phenanthroline, 1mM) inhibits autolysis of sea cucumber body wall.
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In Vivo——
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Synonyms1,10-phenanthroline | Ortho-phenanthroline | OPA
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PathwayProteasome/Ubiquitin
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TargetProteasome
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RecptorProteasome
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Research Area——
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Indication——
Chemical Information
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CAS Number66-71-7
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Formula Weight180.21
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Molecular FormulaC12H8N2
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 100 mg/mL (554.91 mM)
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SMILESC1=CC2=C(C3=C(C=CC=N3)C=C2)N=C1
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Chemical Name4,5-Diazaphenanthrene
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Song Y, et al. Oncogene. 2017 Jun 5. doi: 10.1038/onc.2017.172.
2. Verma R, et al. Science. 2002 Oct 18;298(5593):611-5.
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