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PTP1B-IN-9
CAS No. 145888-79-5
PTP1B-IN-9( —— )
Catalog No. M22017 CAS No. 145888-79-5
PTP1B-IN-9 is a ubiquitin-proteasome system (UPS)-stressor,with anticancer activity. PTP1B-IN-9 reduces the cell viability of exponentially growing HeLa cervical cancer cells in a dose-dependent fashion with an IC50 value of 2 μM[1].
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 30 | In Stock |
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| 5MG | 29 | In Stock |
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| 10MG | 44 | In Stock |
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| 25MG | 74 | In Stock |
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| 50MG | 114 | In Stock |
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| 100MG | 184 | In Stock |
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| 200MG | Get Quote | In Stock |
|
| 500MG | 456 | In Stock |
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| 1G | Get Quote | In Stock |
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Biological Information
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Product NamePTP1B-IN-9
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NoteResearch use only, not for human use.
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Brief DescriptionPTP1B-IN-9 is a ubiquitin-proteasome system (UPS)-stressor,with anticancer activity. PTP1B-IN-9 reduces the cell viability of exponentially growing HeLa cervical cancer cells in a dose-dependent fashion with an IC50 value of 2 μM[1].
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DescriptionPTP1B-IN-9 is a ubiquitin-proteasome system (UPS)-stressor,with anticancer activity. PTP1B-IN-9 reduces the cell viability of exponentially growing HeLa cervical cancer cells in a dose-dependent fashion with an IC50 value of 2 μM.
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In VitroRAMB4 (0-30 μM; 48 hours) treatment produces a dose dependent reduction in the viability of HPV16-positive SiHa and Caski cells and HPV-39-positive ME180 cervical cancer cell lines respectively.RAMB4 reduces the cell viability of exponentially growing HeLa cervical cancer cells in a dose-dependent fashion with an IC50 value of 2 μM. Cell Viability Assay Cell Line:Keratinocytes, SiHa, CaSki and ME180 cells Concentration:5, 10, 15, 20, 25, 30 μM Incubation Time:48 hours Result:Produced a dose dependent reduction in the viability of HPV16-positive SiHa and Caski cells and HPV-39-positive ME180 cervical cancer cell lines respectively with minimal effects on the viability of primary human keratinocytes and with IC50 similar to the obtained with HeLa cells.
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In Vivo——
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Synonyms——
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PathwayProteasome/Ubiquitin
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TargetProteasome
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RecptorProteasome
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Research Area——
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Indication——
Chemical Information
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CAS Number145888-79-5
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Formula Weight413.1
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Molecular FormulaC19H13Cl4NO?
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 5 mg/mL (12.10 mM)
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SMILESClC1=CC=C(\\C=C2/CNC\\C(=C/C3=CC(Cl)=C(Cl)C=C3)C2=O)C=C1Cl
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Anchoori RK, et al. Stressing?the?ubiquitin-proteasome?system?without?20S?proteolytic?inhibition?selectively?kills?cervical?cancer?cells.PLoS One.?2011;6(8):e23888.
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