Cart
sales@molnova.com
PTP1B-IN-9
CAS No. 145888-79-5
PTP1B-IN-9( —— )
Catalog No. M22017 CAS No. 145888-79-5
PTP1B-IN-9 is a ubiquitin-proteasome system (UPS)-stressor,with anticancer activity. PTP1B-IN-9 reduces the cell viability of exponentially growing HeLa cervical cancer cells in a dose-dependent fashion with an IC50 value of 2 μM[1].
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 10MG | 68 | In Stock |
|
| 50MG | 186 | In Stock |
|
| 100MG | 308 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
-
Product NamePTP1B-IN-9
-
NoteResearch use only, not for human use.
-
Brief DescriptionPTP1B-IN-9 is a ubiquitin-proteasome system (UPS)-stressor,with anticancer activity. PTP1B-IN-9 reduces the cell viability of exponentially growing HeLa cervical cancer cells in a dose-dependent fashion with an IC50 value of 2 μM[1].
-
DescriptionPTP1B-IN-9 is a ubiquitin-proteasome system (UPS)-stressor,with anticancer activity. PTP1B-IN-9 reduces the cell viability of exponentially growing HeLa cervical cancer cells in a dose-dependent fashion with an IC50 value of 2 μM.
-
In VitroRAMB4 (0-30 μM; 48 hours) treatment produces a dose dependent reduction in the viability of HPV16-positive SiHa and Caski cells and HPV-39-positive ME180 cervical cancer cell lines respectively.RAMB4 reduces the cell viability of exponentially growing HeLa cervical cancer cells in a dose-dependent fashion with an IC50 value of 2 μM. Cell Viability Assay Cell Line:Keratinocytes, SiHa, CaSki and ME180 cells Concentration:5, 10, 15, 20, 25, 30 μM Incubation Time:48 hours Result:Produced a dose dependent reduction in the viability of HPV16-positive SiHa and Caski cells and HPV-39-positive ME180 cervical cancer cell lines respectively with minimal effects on the viability of primary human keratinocytes and with IC50 similar to the obtained with HeLa cells.
-
In Vivo——
-
Synonyms——
-
PathwayProteasome/Ubiquitin
-
TargetProteasome
-
RecptorProteasome
-
Research Area——
-
Indication——
Chemical Information
-
CAS Number145888-79-5
-
Formula Weight413.1
-
Molecular FormulaC19H13Cl4NO?
-
Purity>98% (HPLC)
-
SolubilityIn Vitro:?DMSO : 5 mg/mL (12.10 mM)
-
SMILESClC1=CC=C(\\C=C2/CNC\\C(=C/C3=CC(Cl)=C(Cl)C=C3)C2=O)C=C1Cl
-
Chemical Name——
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1.Anchoori RK, et al. Stressing?the?ubiquitin-proteasome?system?without?20S?proteolytic?inhibition?selectively?kills?cervical?cancer?cells.PLoS One.?2011;6(8):e23888.
molnova catalog
related products
-
Celastrol
Celastrol (Tripterin) is an active compound extracted from Chinese medicine Thunder of God Vine.
-
Gly-Pro-pNA hydrochl...
Gly-Pro-pNA hydrochloride (Gly-Pro p-nitroanilide hydrochloride) is a dipeptidyl peptidase inhibitor that inhibits dipeptidyl peptidase II, dipeptidyl peptidase IV and dipeptidyl peptidase IX.
-
(R)-MG-132
(R)-MG-132 is the enantiomer of MG-132. (R)-MG-132 stereoisomer is a more potent proteasome inhibitor than MG-132. (R)-MG-132 is studied as a potential chymotrypsin-like inhibitor, trypsin-like, and peptidylglutamyl peptide hydrolyzing activities of proteasome.
