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PD-151746
CAS No. 179461-52-0
PD-151746( PD151746 | PD-151746 )
Catalog No. M12706 CAS No. 179461-52-0
A potent, selective, cell-permeable Calpain inhibitor with Ki of 0.26 uM for m-calpain.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 38 | In Stock |
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| 5MG | 33 | In Stock |
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| 10MG | 56 | In Stock |
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| 25MG | 113 | In Stock |
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| 50MG | 177 | In Stock |
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| 100MG | Get Quote | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NamePD-151746
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NoteResearch use only, not for human use.
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Brief DescriptionA potent, selective, cell-permeable Calpain inhibitor with Ki of 0.26 uM for m-calpain.
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DescriptionA potent, selective, cell-permeable Calpain inhibitor with Ki of 0.26 uM for m-calpain; displays 20-fold selectivity over m-calpain; attenuates the SLLVY-AMC hydrolysis induced by maitotoxin in SY5Y cells; decreases cytotoxicity induced by oxidized low-density lipoprotein (oxLDL) in HMEC-1 cells.
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In Vitro——
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In Vivo——
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SynonymsPD151746 | PD-151746
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PathwayProteasome/Ubiquitin
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TargetProteasome
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Recptorm-calpain|μ-Calpain
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Research AreaOther Indications
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Indication——
Chemical Information
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CAS Number179461-52-0
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Formula Weight237.2501
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Molecular FormulaC11H8FNO2S
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Purity>98% (HPLC)
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SolubilityDMSO: ≥ 37 mg/mL
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SMILESO=C(O)/C(S)=C/C1=CNC2=C1C=C(F)C=C2
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Chemical Name2-Propenoic acid, 3-(5-fluoro-1H-indol-3-yl)-2-mercapto-
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Wang KK, et al. Proc Natl Acad Sci U S A. 1996 Jun 25;93(13):6687-92.
2. Porn-Ares MI, et al. Biochem J. 2003 Sep 1;374(Pt 2):403-11.
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