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PD-151746

CAS No. 179461-52-0

PD-151746( PD151746 | PD-151746 )

Catalog No. M12706 CAS No. 179461-52-0

A potent, selective, cell-permeable Calpain inhibitor with Ki of 0.26 uM for m-calpain.

Purity : >98% (HPLC)

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

Size	Price / USD	Stock	Quantity
1 mL x 10 mM in DMSO	38	In Stock
5MG	33	In Stock
10MG	56	In Stock
25MG	113	In Stock
50MG	177	In Stock
100MG	Get Quote	In Stock
200MG	Get Quote	In Stock
500MG	Get Quote	In Stock
1G	Get Quote	In Stock

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Biological Information

Product Name

PD-151746
Note

Research use only, not for human use.
Brief Description

A potent, selective, cell-permeable Calpain inhibitor with Ki of 0.26 uM for m-calpain.
Description

A potent, selective, cell-permeable Calpain inhibitor with Ki of 0.26 uM for m-calpain; displays 20-fold selectivity over m-calpain; attenuates the SLLVY-AMC hydrolysis induced by maitotoxin in SY5Y cells; decreases cytotoxicity induced by oxidized low-density lipoprotein (oxLDL) in HMEC-1 cells.
In Vitro

——
In Vivo

——
Synonyms

PD151746 | PD-151746
Pathway

Proteasome/Ubiquitin
Target

Proteasome
Recptor

m-calpain|μ-Calpain
Research Area

Other Indications
Indication

——

Chemical Information

CAS Number

179461-52-0
Formula Weight

237.2501
Molecular Formula

C11H8FNO2S
Purity

>98% (HPLC)
Solubility

DMSO: ≥ 37 mg/mL
SMILES

O=C(O)/C(S)=C/C1=CNC2=C1C=C(F)C=C2
Chemical Name

2-Propenoic acid, 3-(5-fluoro-1H-indol-3-yl)-2-mercapto-

Shipping & Storage Information

Storage

(-20℃)
Shipping

With Ice Pack
Stability

≥ 2 years

Reference

1. Wang KK, et al. Proc Natl Acad Sci U S A. 1996 Jun 25;93(13):6687-92. 2. Porn-Ares MI, et al. Biochem J. 2003 Sep 1;374(Pt 2):403-11.

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