Cart
sales@molnova.com
PD-151746
CAS No. 179461-52-0
PD-151746( PD151746 | PD-151746 )
Catalog No. M12706 CAS No. 179461-52-0
A potent, selective, cell-permeable Calpain inhibitor with Ki of 0.26 uM for m-calpain.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 53 | In Stock |
|
| 10MG | 88 | In Stock |
|
| 25MG | 178 | In Stock |
|
| 50MG | 285 | In Stock |
|
| 100MG | Get Quote | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
-
Product NamePD-151746
-
NoteResearch use only, not for human use.
-
Brief DescriptionA potent, selective, cell-permeable Calpain inhibitor with Ki of 0.26 uM for m-calpain.
-
DescriptionA potent, selective, cell-permeable Calpain inhibitor with Ki of 0.26 uM for m-calpain; displays 20-fold selectivity over m-calpain; attenuates the SLLVY-AMC hydrolysis induced by maitotoxin in SY5Y cells; decreases cytotoxicity induced by oxidized low-density lipoprotein (oxLDL) in HMEC-1 cells.
-
In Vitro——
-
In Vivo——
-
SynonymsPD151746 | PD-151746
-
PathwayProteasome/Ubiquitin
-
TargetProteasome
-
Recptorm-calpain|μ-Calpain
-
Research AreaOther Indications
-
Indication——
Chemical Information
-
CAS Number179461-52-0
-
Formula Weight237.2501
-
Molecular FormulaC11H8FNO2S
-
Purity>98% (HPLC)
-
SolubilityDMSO: ≥ 37 mg/mL
-
SMILESO=C(O)/C(S)=C/C1=CNC2=C1C=C(F)C=C2
-
Chemical Name2-Propenoic acid, 3-(5-fluoro-1H-indol-3-yl)-2-mercapto-
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1. Wang KK, et al. Proc Natl Acad Sci U S A. 1996 Jun 25;93(13):6687-92.
2. Porn-Ares MI, et al. Biochem J. 2003 Sep 1;374(Pt 2):403-11.
molnova catalog
related products
-
KDM5-inhibitor
KDM5 inhibitor.
-
Acetyl-Calpastatin (...
Selective calpain inhibitor. Strongly inhibits calpain I (Ki = 0.2 nM) and II but does not inhibit papain, trypsin and cathepsin L (Ki = 6 μM). Increases secretion of amyoid β-protein (Aβ) 42, Aβ40 and Aβ42 ratio.
-
TCH-165
TCH-165 is a specific small molecule modulator of proteasome assembly, regulates the dynamic equilibrium between the 20S and 26S proteasome complexes.
