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MYCMI-6

CAS No. 681282-09-7

MYCMI-6( NSC354961 | MYCMI6 )

Catalog No. M15600 CAS No. 681282-09-7

MYCMI-6 (NSC354961) is a selective, high affinity inhibitor of MYC-MAX interaction.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    MYCMI-6
  • Note
    Research use only, not for human use.
  • Brief Description
    MYCMI-6 (NSC354961) is a selective, high affinity inhibitor of MYC-MAX interaction.
  • Description
    MYCMI-6 (NSC354961) is a selective, high affinity inhibitor of MYC-MAX interaction, blocks MYC-driven transcription and binds selectively to the MYC bHLHZip domain with Kd of 1.6 uM in SPR assay; specifcally targets MYC:MAX interaction without interfering with other MYC activities, selectively suppresses MYC-driven tumor cell growth with high efficacy, efficiently inhibits anchorage-independent growth of MYCN-amplifed neuroblastoma cells with GI50 values of <0.4, 5 and 0.75 μM, respectively; reduces proliferation and induces massive apoptosis in tumor tissue from a MYC-driven xenograft tumor model without severe side effects
  • In Vitro
    Cell Viability Assay Cell Line:MYCN-amplified neuroblastoma cells (IMR-32, Kelly and SK-N-DZ), MYCN-non-amplified neuroblastoma cells (SK-N-F1, SK-N-AS and SK-N-RA)Concentration:6.25?μM Incubation Time:48 hours Result:Reduced growth of the MYCN-amplified cell lines significantly stronger than the MYCN-non-amplified cell lines.
  • In Vivo
    Animal Model:6-8 weeks old athymic nude mice (bearing MYCN-amplified SK-N-DZ neuroblastoma cells) Dosage:20?mg/kg body weight Administration:I.p.; daily for 1-2 weeks Result:A dramatic increase in the extension of apoptotic areas in the tumors and a significant increase in non-proliferative areas as determined by Ki67 staining in tumors.
  • Synonyms
    NSC354961 | MYCMI6
  • Pathway
    Cell Cycle/DNA Damage
  • Target
    c-Myc
  • Recptor
    c-Myc
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    681282-09-7
  • Formula Weight
    373.42
  • Molecular Formula
    C20H19N7O
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 2.4 mg/mL (6.43 mM)
  • SMILES
    CCOC1=CC2=C(C3=C(C=C(C=C3)N=NC4=C(N=C(C=C4)N)N)N=C2C=C1)N
  • Chemical Name
    (E)-3-((9-amino-7-ethoxyacridin-3-yl)diazenyl)pyridine-2,6-diamine

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Castell A, et al. Sci Rep. 2018 Jul 3;8(1):10064.
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