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MYCi975
CAS No. 2289691-01-4
MYCi975( NUCC-0200975 )
Catalog No. M22558 CAS No. 2289691-01-4
MYCi975 is an orally active inhibitor of MYC.MYCi975 inhibits P493-6, MV411,SK-N-B2 cells viability in an MYC-dependent manner(IC50s of 3.7, 3.9, 6.4 μM, respectively).The initial lead, MYC inhibitor 361 (MYCi361), suppressed in vivo tumor growth in mice, increased tumor immune cell infiltration, upregulated PD-L1 on tumors, and sensitized tumors to anti-PD1 immunotherapy. However, 361 demonstrated a narrow therapeutic index.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 267 | In Stock |
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| 10MG | 443 | In Stock |
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| 25MG | 737 | In Stock |
|
| 50MG | 1017 | In Stock |
|
| 100MG | 1377 | In Stock |
|
| 500MG | 2673 | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameMYCi975
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NoteResearch use only, not for human use.
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Brief DescriptionMYCi975 is an orally active inhibitor of MYC.MYCi975 inhibits P493-6, MV411,SK-N-B2 cells viability in an MYC-dependent manner(IC50s of 3.7, 3.9, 6.4 μM, respectively).The initial lead, MYC inhibitor 361 (MYCi361), suppressed in vivo tumor growth in mice, increased tumor immune cell infiltration, upregulated PD-L1 on tumors, and sensitized tumors to anti-PD1 immunotherapy. However, 361 demonstrated a narrow therapeutic index.
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DescriptionMYCi975 is an orally active inhibitor of MYC.MYCi975 inhibits P493-6, MV411,SK-N-B2 cells viability in an MYC-dependent manner(IC50s of 3.7, 3.9, 6.4 μM, respectively)[1].The initial lead, MYC inhibitor 361 (MYCi361), suppressed in vivo tumor growth in mice, increased tumor immune cell infiltration, upregulated PD-L1 on tumors, and sensitized tumors to anti-PD1 immunotherapy. However, 361 demonstrated a narrow therapeutic index. An improved analog, MYCi975 showed better tolerability.?
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In Vitro——
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In Vivo——
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SynonymsNUCC-0200975
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PathwayCell Cycle/DNA Damage
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Targetc-Myc
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RecptorMYC
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Research Area——
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Indication——
Chemical Information
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CAS Number2289691-01-4
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Formula Weight561.3
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Molecular FormulaC25H16Cl2F6N2O2
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Purity>98% (HPLC)
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SolubilityDMSO:247 mg/mL (440.05mM)
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SMILESCn1nc(cc1-c1ccc(OCc2ccc(Cl)cc2)c(-c2ccc(Cl)c(c2)C(F)(F)F)c1O)C(F)(F)F
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Han H, et al. Small-Molecule MYC Inhibitors Suppress Tumor Growth and Enhance Immunotherapy. Cancer Cell. 2019 Nov 11;36(5):483-497.e15.
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