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IRES-J007
CAS No. 155514-72-0
IRES-J007( IRESJ007 | IRES J007 )
Catalog No. M12211 CAS No. 155514-72-0
An improved IRES inhibitor that blocks IRES-hnRNP A1 binding.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 100MG | Get Quote | Get Quote |
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| 200MG | Get Quote | Get Quote |
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| 500MG | Get Quote | Get Quote |
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| 1G | Get Quote | Get Quote |
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Biological Information
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Product NameIRES-J007
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NoteResearch use only, not for human use.
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Brief DescriptionAn improved IRES inhibitor that blocks IRES-hnRNP A1 binding.
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DescriptionAn improved IRES inhibitor that blocks IRES-hnRNP A1 binding; binds to a small pocket structure within the RRM-containing fragment of hnRNP A1 (UP1 fragment), inhibits cyclin D1 and c-MYC IRES activity to a greater extent compared with C11 (IRES-C11); significantly reduces tumor growth of GBM xenografts in mice, and markedly reduces the mRNA translational state of cyclin D1 and c-MYC transcripts combined with PP242.
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In Vitro——
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In Vivo——
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SynonymsIRESJ007 | IRES J007
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PathwayCell Cycle/DNA Damage
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Targetc-Myc
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Recptorc-Myc
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Research Area——
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Indication——
Chemical Information
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CAS Number155514-72-0
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Formula Weight297.31
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Molecular FormulaC17H15NO4
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Purity>98% (HPLC)
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Solubility——
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SMILES——
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Chemical Name2-((2,4-Dimethoxyphenyl)methyl)isoindoline-1,3-dione
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Holmes B, et al. J Biol Chem. 2016 Jul 1;291(27):14146-59.
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