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Home - Products - Cell Cycle/DNA Damage - c-Myc - IRES-J007

IRES-J007

CAS No. 155514-72-0

IRES-J007( IRESJ007 | IRES J007 )

Catalog No. M12211 CAS No. 155514-72-0

An improved IRES inhibitor that blocks IRES-hnRNP A1 binding.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    IRES-J007
  • Note
    Research use only, not for human use.
  • Brief Description
    An improved IRES inhibitor that blocks IRES-hnRNP A1 binding.
  • Description
    An improved IRES inhibitor that blocks IRES-hnRNP A1 binding; binds to a small pocket structure within the RRM-containing fragment of hnRNP A1 (UP1 fragment), inhibits cyclin D1 and c-MYC IRES activity to a greater extent compared with C11 (IRES-C11); significantly reduces tumor growth of GBM xenografts in mice, and markedly reduces the mRNA translational state of cyclin D1 and c-MYC transcripts combined with PP242.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    IRESJ007 | IRES J007
  • Pathway
    Cell Cycle/DNA Damage
  • Target
    c-Myc
  • Recptor
    c-Myc
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    155514-72-0
  • Formula Weight
    297.31
  • Molecular Formula
    C17H15NO4
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    ——
  • Chemical Name
    2-((2,4-Dimethoxyphenyl)methyl)isoindoline-1,3-dione

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Holmes B, et al. J Biol Chem. 2016 Jul 1;291(27):14146-59.
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