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APTO-253 isomer

CAS No. 1422826-80-9

APTO-253 isomer( APTO253 | LOR253 | LOR-253 )

Catalog No. M11778 CAS No. 1422826-80-9

APTO-253 is a small molecule inducer of KLF4, stabilizes G-quadruplex DNA and reduces MYC mRNA expression and protein levels.

Purity : >98% (HPLC)

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Biological Information

  • Product Name
    APTO-253 isomer
  • Note
    Research use only, not for human use.
  • Brief Description
    APTO-253 is a small molecule inducer of KLF4, stabilizes G-quadruplex DNA and reduces MYC mRNA expression and protein levels.
  • Description
    APTO-253 is a small molecule inducer of KLF4, stabilizes G-quadruplex DNA and reduces MYC mRNA expression and protein levels; APTO-253 is converted intracellularly from a monomer to a ferrous complex [Fe(253)3]; selectively induces CDKN1A (p21), promotes G0-G1 cell-cycle arrest, and triggers apoptosis in acute myeloid leukemia (AML) cells without producing myelosuppression in various animal species and humans, induces DNA Damage in AML cells.Blood Cancer Phase 1 Clinical.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    APTO253 | LOR253 | LOR-253
  • Pathway
    Cell Cycle/DNA Damage
  • Target
    c-Myc
  • Recptor
    c-Myc
  • Research Area
    Cancer
  • Indication
    Blood cancer

Chemical Information

  • CAS Number
    1422826-80-9
  • Formula Weight
    367.387
  • Molecular Formula
    C22H14FN5
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    CC(N1)=C(C2=NC3=C4C=CC=NC4=C5N=CC=CC5=C3N2)C6=C1C=C(F)C=C6
  • Chemical Name
    2-(6-fluoro-2-methyl-1H-indol-3-yl)-1H-imidazo[4,5-f][1,10]phenanthroline

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Tsai CY, et al. Mol Cancer Ther. 2018 Apr 6. doi: 10.1158/1535-7163.MCT-17-0834. 2. Cercek A, et al. Invest New Drugs. 2015 Oct;33(5):1086-92. 3. Wang B, et al. Biochem Biophys Res Commun. 2017 Mar 11;484(3):486-492. 4. Local A, et al. Mol Cancer Ther. 2018 Apr 6. doi: 10.1158/1535-7163.MCT-17-1209.
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