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MNKI-8e
CAS No. 1610886-04-8
MNKI-8e( MNK inhibitor 8e )
Catalog No. M12328 CAS No. 1610886-04-8
MNKI-8e (MNK inhibitor 8e) is a potent, selective MNK inhibitor that inhibits Mnk2 with Ki of 0.37 uM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
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Biological Information
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Product NameMNKI-8e
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NoteResearch use only, not for human use.
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Brief DescriptionMNKI-8e (MNK inhibitor 8e) is a potent, selective MNK inhibitor that inhibits Mnk2 with Ki of 0.37 uM.
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DescriptionMNKI-8e (MNK inhibitor 8e) is a potent, selective MNK inhibitor that inhibits Mnk2 with Ki of 0.37 uM, displays >34-fold and 4-fold over CDK2 (Ki>10 uM) and CDK9 (Ki=1.66 uM); potently inhibits leukemia cells with GI50 of 1.23-7.36 uM (MV4-11 GI50=1.32 uM and KG-1 GI50=1.23 uM); blocks phosphorylation of eIF4E, downregulates anti-apoptotic protein Mcl-1 and induces apoptosis in AML cells; suppresses the Ara-C-induced MAPK activity and enhances apoptosis in MV4-11 cells.
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In Vitro——
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In Vivo——
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SynonymsMNK inhibitor 8e
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PathwayMAPK/ERK Signaling
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TargetMNK
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RecptorMNK
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Research Area——
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Indication——
Chemical Information
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CAS Number1610886-04-8
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Formula Weight358.416
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Molecular FormulaC17H18N4O3S
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Purity>98% (HPLC)
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Solubility——
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SMILES——
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Chemical Name5-(2-((2,4-dimethoxyphenyl)amino)pyrimidin-4-yl)-3,4-dimethylthiazol-2(3H)-one
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Diab S, et al. ChemMedChem. 2014 May;9(5):962-72.
2. Li P, et al. Oncotarget. 2016 Aug 30;7(35):56811-56825.
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