MNK-IN-54( —— )

Catalog No. M12337 CAS No. 1613168-64-1

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Datasheet

HNMR

HPLC

MSDS

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Product Name

MNK-IN-54
Note

Research use only, not for human use.
Brief Description

MNK-IN-54 is a potent, orally bioavailable dual MNK1/2 and BCR-ABL1 inhibitor.
Description

MNK-IN-54 is a potent, orally bioavailable dual MNK1/2 and BCR-ABL1 inhibitor with IC50 of 20/10/200/10 nM for Abl T315I/ wt Abl/MNK1/MNK2, respectively; also inhibits RET, FLT3, VEGFR2 with IC50 <20 nM; shows GI50 of 51 nM in the growth of K562 cells overexpressing eIF4E; exhibits antitumor activity in a mouse xenograft model and also reduces the level of phosphorylated eukaryotic translation initiation factor 4E in the tumor tissues.
In Vitro

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In Vivo

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Synonyms

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Pathway

MAPK/ERK Signaling
Target

MNK
Recptor

MNK
Research Area

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Indication

——

CAS Number

1613168-64-1
Formula Weight

584.62
Molecular Formula

C30H32F4N6O2
Purity

>98% (HPLC)
Solubility

——
SMILES

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Chemical Name

N-(5-(3-Fluoro-4-((2-((4-((4-methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)phenyl)-amino)-2-oxoethyl)amino)phenyl)pyridin-2-yl)cyclopropanecarboxamide

1. Cherian J, et al. J Med Chem. 2016 Apr 14;59(7):3063-78.

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