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MNKI-85
CAS No. 1812885-57-6
MNKI-85( MNKI85 )
Catalog No. M12783 CAS No. 1812885-57-6
MNKI-85 is a potent and selective Mnk2 inhibitor with Ki of 31 nM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
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Biological Information
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Product NameMNKI-85
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NoteResearch use only, not for human use.
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Brief DescriptionMNKI-85 is a potent and selective Mnk2 inhibitor with Ki of 31 nM.
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DescriptionMNKI-85 is a potent and selective Mnk2 inhibitor with Ki of 31 nM, displays no inhibitory activities against Mnk1, CDK2A, CDK9T, and CDK4D; effectively inhibits the growth of AML cells that possess an M5 subtype with FLT3-internal tandem duplication mutation, a powerful pharmacologic tool in studying the Mnk2/eIF4E-mediated tumorigenic mechanism.
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In Vitro——
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In Vivo——
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SynonymsMNKI85
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PathwayMAPK/ERK Signaling
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TargetMNK
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RecptorMNK
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Research Area——
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Indication——
Chemical Information
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CAS Number1812885-57-6
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Formula Weight418.487
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Molecular FormulaC20H23FN4O3S
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Purity>98% (HPLC)
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Solubility——
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SMILES——
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Chemical Name4-[[4-Fluoro-2-(1-methylethoxy)phenyl]amino]-N-(2-methoxyethyl)-5-methyl-thieno[2,3-d]pyrimidine-6-carboxamide
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Teo T, et al. Mol Pharmacol. 2015 Aug;88(2):380-9.
molnova catalog
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EB1
EB1 is a potent and selective MNK kinase inhibitor with inhibitory effects on MNK1 and MNK2 with IC50 values of 0.69 μM and 9.4 μM, respectively.
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MNKI-19
MNKI-19 is a potent and dual-specific Mnk inhibitor with Ki of 186 nM and 68 nM for Mnk1 and Mnk2, respectively.
