MNKI-19( MNKI19 )

Catalog No. M10791 CAS No. 1211757-83-3

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

MNKI-19
Note

Research use only, not for human use.
Brief Description

MNKI-19 is a potent and dual-specific Mnk inhibitor with Ki of 186 nM and 68 nM for Mnk1 and Mnk2, respectively.
Description

MNKI-19 is a potent and dual-specific Mnk inhibitor with Ki of 186 nM and 68 nM for Mnk1 and Mnk2, respectively; only displays moderate activity against Pim-1 (Ki=2.35 uM) in a panel of upstream activating kinases of Mnks, including B-Raf, MAPK1, MAPK2, Akt1, PI3K, p38α, and mTOR; inhibits the phosphorylation of eIF4E and 4E-BP1, arrests cancer cells in the G1 phase and induce apoptosis in FLT3-ITD expressed AML cells.
In Vitro

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In Vivo

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Synonyms

MNKI19
Pathway

MAPK/ERK Signaling
Target

MNK
Recptor

MNK
Research Area

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Indication

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CAS Number

1211757-83-3
Formula Weight

361.391
Molecular Formula

C17H16FN3O3S
Purity

>98% (HPLC)
Solubility

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SMILES

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Chemical Name

4-((4-fluoro-2-isopropoxyphenyl)amino)-5-methylthieno[2,3-d]pyrimidine-6-carboxylic acid

1. Teo T, et al. Mol Pharmacol. 2015 Aug;88(2):380-9.

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