EB1

Research use only, not for human use.

EB1 is a potent and selective MNK kinase inhibitor with inhibitory effects on MNK1 and MNK2 with IC50 values of 0.69 μM and 9.4 μM, respectively.

EB1 is the inhibitor of kinases MNK with IC50s of 0.69 μM (MNK1) and 9.4 μM (MNK2). EB1 selectively inhibits the growth of cancer cells, but not normal cells. EB1 also increases cell apoptosis and suppresses eIF4E phosphorylation.

Western Blot Analysis Cell Line:MDA-MB-231, MDA-MB-468, MCF7, and IMR90 cells Concentration:1.3 μM, 2.5 μM, 5 μM, 10 μM, 20 μM, 40 μM Incubation Time:24 hours Result:Blocked the phosphorylation of eIF4E in a dose-dependent manner.Apoptosis Analysis Cell Line:MDA-MB-231, MDA-MB-468, MCF7, and IMR90 cells Concentration:2.5 μM, 5 μM, 10 μM, 20 μM, 40 μM Incubation Time:72 hours Result:Increased the percentage of apoptosis cells among tumor cells.

——

——

MAPK/ERK Signaling

MNK

MNK

——

——

42951-68-8

286.33

C18H14N4

>98% (HPLC)

——

NC=1C2=C(C=C(N=C2NN1)C3=CC=CC=C3)C4=CC=CC=C4

——

(-20℃)

With Ice Pack

≥ 2 years