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CGP 57380

CAS No. 522629-08-9

CGP 57380( CGP57380 | CGP-57380 )

Catalog No. M14845 CAS No. 522629-08-9

A cell-permeable, specific MNK1 inhibitor with IC50 of 2.2 uM.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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5MG 83 In Stock
10MG 131 In Stock
25MG 248 In Stock
50MG 412 In Stock
100MG 593 In Stock
200MG 831 In Stock
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Biological Information

  • Product Name
    CGP 57380
  • Note
    Research use only, not for human use.
  • Brief Description
    A cell-permeable, specific MNK1 inhibitor with IC50 of 2.2 uM.
  • Description
    A cell-permeable, specific MNK1 inhibitor with IC50 of 2.2 uM; has no inhibitory activity on p38, JNK1, ERK1/2, etc.; inhibits phosphorylation of eIF4E in cellular assays with IC50 of 3 uM.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    CGP57380 | CGP-57380
  • Pathway
    MAPK/ERK Signaling
  • Target
    MNK
  • Recptor
    MNK1
  • Research Area
    Cancer
  • Indication
    ——

Chemical Information

  • CAS Number
    522629-08-9
  • Formula Weight
    244.2278
  • Molecular Formula
    C11H9FN6
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO: ≥ 43 mg/mL
  • SMILES
    NC1=C2C(NN=C2NC3=CC=C(F)C=C3)=NC=N1
  • Chemical Name
    1H-Pyrazolo[3,4-d]pyrimidine-3,4-diamine, N3-(4-fluorophenyl)-

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Knauf U, et al. Mol Cell Biol. 2001 Aug;21(16):5500-11. 2. Wen Q, et al. Oncotarget. 2016 May 10;7(19):27787-801. 3. Lim S, et al. Proc Natl Acad Sci U S A. 2013 Jun 18;110(25):E2298-307.
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