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CGP 57380
CAS No. 522629-08-9
CGP 57380( CGP57380 | CGP-57380 )
Catalog No. M14845 CAS No. 522629-08-9
A cell-permeable, specific MNK1 inhibitor with IC50 of 2.2 uM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 79 | In Stock |
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| 5MG | 71 | In Stock |
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| 10MG | 113 | In Stock |
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| 25MG | 233 | In Stock |
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| 50MG | 342 | In Stock |
|
| 100MG | 514 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameCGP 57380
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NoteResearch use only, not for human use.
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Brief DescriptionA cell-permeable, specific MNK1 inhibitor with IC50 of 2.2 uM.
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DescriptionA cell-permeable, specific MNK1 inhibitor with IC50 of 2.2 uM; has no inhibitory activity on p38, JNK1, ERK1/2, etc.; inhibits phosphorylation of eIF4E in cellular assays with IC50 of 3 uM.
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In Vitro——
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In Vivo——
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SynonymsCGP57380 | CGP-57380
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PathwayMAPK/ERK Signaling
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TargetMNK
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RecptorMNK1
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Research AreaCancer
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Indication——
Chemical Information
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CAS Number522629-08-9
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Formula Weight244.2278
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Molecular FormulaC11H9FN6
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Purity>98% (HPLC)
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SolubilityDMSO: ≥ 43 mg/mL
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SMILESNC1=C2C(NN=C2NC3=CC=C(F)C=C3)=NC=N1
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Chemical Name1H-Pyrazolo[3,4-d]pyrimidine-3,4-diamine, N3-(4-fluorophenyl)-
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Knauf U, et al. Mol Cell Biol. 2001 Aug;21(16):5500-11.
2. Wen Q, et al. Oncotarget. 2016 May 10;7(19):27787-801.
3. Lim S, et al. Proc Natl Acad Sci U S A. 2013 Jun 18;110(25):E2298-307.
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