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Ac-IETD-pNA

CAS No. 219138-21-3

Ac-IETD-pNA( ——— )

Catalog No. M41648 CAS No. 219138-21-3

Ac-Ile-Glu-Thr-Asp-pNA is a substrate for caspase-8.Caspase-8 binds to and cleaves the Ile-Glu-Thr-Asp (IETD) peptide sequence to release p-nitroalinide, which can be quantified by colorimetric detection at 405 nm as a measure of enzyme activity.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    Ac-IETD-pNA
  • Note
    Research use only, not for human use.
  • Brief Description
    Ac-Ile-Glu-Thr-Asp-pNA is a substrate for caspase-8.Caspase-8 binds to and cleaves the Ile-Glu-Thr-Asp (IETD) peptide sequence to release p-nitroalinide, which can be quantified by colorimetric detection at 405 nm as a measure of enzyme activity.
  • Description
    Ac-Ile-Glu-Thr-Asp-pNA is a substrate for caspase-8.Caspase-8 binds to and cleaves the Ile-Glu-Thr-Asp (IETD) peptide sequence to release p-nitroalinide, which can be quantified by colorimetric detection at 405 nm as a measure of enzyme activity.
  • In Vitro
    ———
  • In Vivo
    ———
  • Synonyms
    ———
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    ———
  • Research Area
    ———
  • Indication
    ———

Chemical Information

  • CAS Number
    219138-21-3
  • Formula Weight
    638.6
  • Molecular Formula
    C27H38N6O12
  • Purity
    >98% (HPLC)
  • Solubility
    H2O : 0.98 mg/mL (1.53 mM; adjust pH to 12 with 1 M NaOH)
  • SMILES
    ———
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Smith GK, et al. Expression, preparation, and high-throughput screening of caspase-8: discovery of redox-based and steroid diacid inhibition. Arch Biochem Biophys. 2002;399(2):195-205.?
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