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MMG-11
CAS No. 313254-94-3
MMG-11( ——— )
Catalog No. M39428 CAS No. 313254-94-3
MMG-11 is a potent and selective human TLR2 antagonist with low cytotoxicity. MMG-11 inhibits both TLR2/1 and TLR2/6 signaling with IC50s of 1.7 μM for Pam3CSK4-induced hTLR2/1 and 5.7 μM for Pam2CSK4-induced hTLR2/6 responses.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 123 | In Stock |
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| 10MG | 194 | In Stock |
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| 25MG | Get Quote | In Stock |
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| 50MG | Get Quote | In Stock |
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| 100MG | Get Quote | In Stock |
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Biological Information
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Product NameMMG-11
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NoteResearch use only, not for human use.
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Brief DescriptionMMG-11 is a potent and selective human TLR2 antagonist with low cytotoxicity. MMG-11 inhibits both TLR2/1 and TLR2/6 signaling with IC50s of 1.7 μM for Pam3CSK4-induced hTLR2/1 and 5.7 μM for Pam2CSK4-induced hTLR2/6 responses.
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DescriptionMMG-11 inhibits both TLR2/1 and TLR2/6 signaling (IC50s: 1.7 μM for Pam3CSK4-induced hTLR2/1 and 5.7 μM for Pam2CSK4-induced hTLR2/6 responses).
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In VitroCell Cytotoxicity Assay Cell Line:PBMCs Concentration:0.01, 1, 10, 100?μM Incubation Time:Result:Showed no cytotoxic effects up to 100?μM.
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In Vivo———
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Synonyms———
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PathwayImmunology/Inflammation
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TargetTLR
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RecptorTLR2
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Research Area———
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Indication———
Chemical Information
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CAS Number313254-94-3
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Formula Weight306.27
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Molecular FormulaC15H14O7
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Purity>98% (HPLC)
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SolubilityDMSO : 100 mg/mL (326.51 mM; ultraphonic; )
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SMILES———
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Grabowski M, et al. Identification of a pyrogallol derivative as a potent and selective human TLR2 antagonist by structure-based virtual screening. Biochem Pharmacol. 2018 Aug;154:148-160.?
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