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L-655708

CAS No. 130477-52-0

L-655708( —— )

Catalog No. M37943 CAS No. 130477-52-0

L-655708 is a selective and highly potent GABAA receptor reverse agonist with a Ki value of 0.45 nM.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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1 mL x 10 mM in DMSO 81 In Stock
5MG 73 In Stock
10MG 121 In Stock
25MG 250 In Stock
50MG 481 In Stock
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Biological Information

  • Product Name
    L-655708
  • Note
    Research use only, not for human use.
  • Brief Description
    L-655708 is a selective and highly potent GABAA receptor reverse agonist with a Ki value of 0.45 nM.
  • Description
    L-655708 is a potent α5 subunit-selective GABAA receptor inverse agonist (Ki=0.45 nM).
  • In Vitro
    L655708 is a potent, selective inverse agonist for the benzodiazepine site of GABAA receptors containing the α5 subunit (Ki = 0.45 nM). Displays 50-100-fold selectivity over GABAA receptors containing α1, α2, α3 orα6 subunits in combination with β3 and γ2. Enhances LTP in a mouse hippocampal slice model and increases spatial learning, without displaying proconvulsant activity.
  • In Vivo
    L-655708 at 0.7 mg/kg, administered intraperitoneally, would result in 60-70% occupancy of α5 GABAA receptors with limited binding to α1, α2, and α3 subunit-containing GABAA receptors and no significant off-target behavioral effects, such as sedation and motor impairment.
  • Synonyms
    ——
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    GABA Receptor
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    130477-52-0
  • Formula Weight
    341.36
  • Molecular Formula
    C18H19N3O4
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 10 mg/mL (29.29 mM; Ultrasonic (<60°C)
  • SMILES
    [H][C@@]12CCCN1C(=O)c1cc(OC)ccc1-n1cnc(C(=O)OCC)c21
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Saab BJ, et al. Short-term memory impairment after isoflurane in mice is prevented by the α5 γ-aminobutyric acid type A receptorinverse agonist L-655708. Anesthesiology. 2010 Nov;113(5):1061-1071.?
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