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Nedometinib
CAS No. 2252314-46-6
Nedometinib( —— )
Catalog No. M37153 CAS No. 2252314-46-6
Nedometinib (NFX-179) is a selective mitogen-activated protein kinase kinase (MEK1) inhibitor with anticancer and antitumor activity, inhibits MAPK pathway signaling in the skin, inhibits the growth of human squamous cell lines in a dose-dependent manner, and can be used to study malignant tumors.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 154 | In Stock |
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| 5MG | 148 | In Stock |
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| 10MG | 226 | In Stock |
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| 25MG | 372 | In Stock |
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| 50MG | 554 | In Stock |
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| 100MG | 732 | In Stock |
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| 200MG | Get Quote | In Stock |
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| 500MG | Get Quote | In Stock |
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| 1G | Get Quote | In Stock |
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Biological Information
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Product NameNedometinib
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NoteResearch use only, not for human use.
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Brief DescriptionNedometinib (NFX-179) is a selective mitogen-activated protein kinase kinase (MEK1) inhibitor with anticancer and antitumor activity, inhibits MAPK pathway signaling in the skin, inhibits the growth of human squamous cell lines in a dose-dependent manner, and can be used to study malignant tumors.
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DescriptionNedometinib is a tyrosine kinase inhibitor targeting to MEK1. Nedometinib has antineoplastic effect and can be used for research in dermatosis, cutaneous fibroneuroma, neurofibromatosis.
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In Vitro——
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In Vivo——
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Synonyms——
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PathwayMAPK/ERK Signaling
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TargetMEK
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RecptorMEK
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Research Area——
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Indication——
Chemical Information
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CAS Number2252314-46-6
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Formula Weight470.24
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Molecular FormulaC17H16FIN4O3
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 100 mg/mL (212.66 mM; Ultrasonic )
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SMILESO=C(NOCCO)C=1C=2C=CC=NC2N(C1NC3=CC=C(I)C=C3F)C
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Kincaid, et al. Preparation of pyrrolopyridine-aniline compounds for treatment of dermal disorders. World Intellectual Property Organization, WO2018213810 A1. 2018-11-22.
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