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PD318088
CAS No. 391210-00-7
PD318088( PD 318088 | PD-318088 )
Catalog No. M14344 CAS No. 391210-00-7
PD318088 is a potent, non-ATP competitive, allosteric MEK1/2 inhibitor.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 75 | In Stock |
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| 5MG | 120 | In Stock |
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| 10MG | 227 | In Stock |
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| 25MG | 426 | In Stock |
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| 50MG | 626 | In Stock |
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| 100MG | 888 | In Stock |
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| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NamePD318088
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NoteResearch use only, not for human use.
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Brief DescriptionPD318088 is a potent, non-ATP competitive, allosteric MEK1/2 inhibitor.
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DescriptionPD318088 is a potent, non-ATP competitive, allosteric MEK1/2 inhibitor, binds simultaneously with ATP in a region of the MEK1 active site that is adjacent to the ATP-binding site.
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In Vitro——
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In Vivo——
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SynonymsPD 318088 | PD-318088
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PathwayMAPK/ERK Signaling
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TargetMEK
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RecptorMEK1|MEK2
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Research AreaCancer
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Indication——
Chemical Information
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CAS Number391210-00-7
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Formula Weight561.0891
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Molecular FormulaC16H13BrF3IN2O4
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Purity>98% (HPLC)
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Solubility10 mM in DMSO
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SMILESO=C(NOCC(O)CO)C1=CC(Br)=C(F)C(F)=C1NC2=CC=C(I)C=C2F
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Chemical NameBenzamide, 5-bromo-N-(2,3-dihydroxypropoxy)-3,4-difluoro-2-[(2-fluoro-4-iodophenyl)amino]-
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Han S, et al. Bioorg Med Chem Lett. 2005 Dec 15;15(24):5467-73.
2. Zhang Y, et al. Mol Med Rep. 2014 Jan;9(1):83-90.
3. Ohren JF, et al. Nat Struct Mol Biol. 2004 Dec;11(12):1192-7.
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