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Demcizumab
CAS No. 1243262-17-0
Demcizumab( —— )
Catalog No. M36721 CAS No. 1243262-17-0
Demcizumab (OMP 21M18) is an anti-DLL4 monoclonal antibody and a potent Notch pathway inhibitor, demonstrating efficacy in various cancer models both as a monotherapy and in conjunction with chemotherapy agents.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 565 | Get Quote |
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| 5MG | 886 | Get Quote |
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| 10MG | 1416 | Get Quote |
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| 500MG | Get Quote | Get Quote |
|
| 1G | Get Quote | Get Quote |
|
Biological Information
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Product NameDemcizumab
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NoteResearch use only, not for human use.
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Brief DescriptionDemcizumab (OMP 21M18) is an anti-DLL4 monoclonal antibody and a potent Notch pathway inhibitor, demonstrating efficacy in various cancer models both as a monotherapy and in conjunction with chemotherapy agents.
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DescriptionDemcizumab (OMP 21M18) is an anti-DLL4 monoclonal antibody. Demcizumab is a potent inhibitor of the Notch pathway. Demcizumab alone or in combination with chemotherapy is effective in various cancer models.
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In VitroCell Viability AssayCell Line:PDTALL13 (patient-derived T-ALL 13) cell Concentration:0, 0.5, 1, 5, 10, 20, 40, 80 μg/mL Incubation Time:1 or 2 or 3 days Result:Dose-dependently inhibited cell viability.
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In VivoAnimal Model:KRASWT and KRASMT CRC xenografts Dosage:10 mg/kg, together with Irinotecan (HY-16562) (7.5 mg/kg) Administration:Intraperitoneal injection (i.p.), once a week Result:Resulted in tumor regression at day 20.
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Synonyms——
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PathwayNeuroscience
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TargetGamma-secretase
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RecptorGamma-secretase
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Research Area——
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Indication——
Chemical Information
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CAS Number1243262-17-0
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Formula Weight145.65 (kDa)
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Molecular Formula——
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Purity>98% (HPLC)
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Solubility——
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SMILES——
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Smith DC, et al. A phase I dose escalation and expansion study of the anticancer stem cell agent demcizumab (anti-DLL4) in patients with previously treated solid tumors. Clin Cancer Res. 2014 Dec 15;20(24):6295-303. ?
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