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TLR7/8 agonist 1

CAS No. 1258457-59-8

TLR7/8 agonist 1( —— )

Catalog No. M36362 CAS No. 1258457-59-8

TLR7/8 agonist 1 is a toll-like receptor TLR7/TLR8 agonist with anticancer and antiviral activities and can be used to study immune-related diseases.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    TLR7/8 agonist 1
  • Note
    Research use only, not for human use.
  • Brief Description
    TLR7/8 agonist 1 is a toll-like receptor TLR7/TLR8 agonist with anticancer and antiviral activities and can be used to study immune-related diseases.
  • Description
    TLR7/8 agonist 1 is a toll-like receptor (TLR7)/TLR8 dual-agonistic imidazoquinoline.
  • In Vitro
    TLR7/8 agonist 1 (Compound 5d) shows prominent immunostimulatory activities. TLR7/8 agonist 1 serves as a convenient precursor for the covalent attachment of fluorophores without significant loss of activity.TLR7/8 agonist 1 retains TLR7-agonistic activity with an EC50 of 20 nM. TLR7/8 agonist 1 is covalently coupled directly to commercially-available fluorescein isothiocyanate and rhodamine B isothiocyanate. TLR7/8 agonist 1 (Compound 1) shows substantially different agonistic potencies in human TLR7 (50 nM) and TLR8 (55 nM) primary screens.
  • In Vivo
    ——
  • Synonyms
    ——
  • Pathway
    Immunology/Inflammation
  • Target
    TLR
  • Recptor
    TLR
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    1258457-59-8
  • Formula Weight
    359.47
  • Molecular Formula
    C22H25N5
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 11.11 mg/mL (30.91 mM; Ultrasonic (<60°C)
  • SMILES
    N1=C(N)C=2N=C(N(C2C=3C=CC=CC13)CC4=CC=C(C=C4)CN)CCCC
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Shukla NM, et al. Syntheses of fluorescent imidazoquinoline conjugates as probes of Toll-like receptor 7. Bioorg Med Chem Lett. 2010 Nov 15;20(22):6384-6.?
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