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Telratolimod

CAS No. 1359993-59-1

Telratolimod( MEDI9197 | 3M-052 )

Catalog No. M26840 CAS No. 1359993-59-1

Telratolimod is a toll-like receptors 7/8 agonist. It has an antitumor activity.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    Telratolimod
  • Note
    Research use only, not for human use.
  • Brief Description
    Telratolimod is a toll-like receptors 7/8 agonist. It has an antitumor activity.
  • Description
    Telratolimod is a toll-like receptors 7/8 agonist. It has an antitumor activity.(In Vivo):Telratolimod (50 μg) suppresses the tumor volume and more effectively blocks tumor growth in combination with CpG ODN in BALB/c mice bearing CT26 colon carcinoma cells. Telratolimod (100 μg) plus 200 μg of CpG ODN slows tumor growth and prolongs the survival of mice bearing large tumors .
  • In Vitro
    Telratolimod (3M-052) is a toll like receptors 7/8 (TLR7/8) agonist, with antitumor activity.
  • In Vivo
    Telratolimod (50 μg) inhibits the tumor volume, and more potently blocks tumor gowth in combination with CpG ODN in BALB/c mice bearing CT26 colon carcinoma cells. Telratolimod (100 μg) plus 200 μg of CpG ODN slows tumor growth and prolongs survival of mice bearing large tumors.
  • Synonyms
    MEDI9197 | 3M-052
  • Pathway
    Immunology/Inflammation
  • Target
    TLR
  • Recptor
    LpxC
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    1359993-59-1
  • Formula Weight
    593.901
  • Molecular Formula
    C36H59N5O2
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 62.5 mg/mL (105.24 mM)
  • SMILES
    CCCCCCCCCCCCCCCCCC(=O)NCCCCOn1c(CCCC)nc2c(N)nc3ccccc3c12
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Ushiyama F, et al. Lead optimization of 2-hydroxymethyl imidazoles as non-hydroxamate LpxC inhibitors: Discovery of TP0586532. Bioorg Med Chem. 2021;30:115964.
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