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Camlipixant
CAS No. 1621164-74-6
Camlipixant( —— )
Catalog No. M36052 CAS No. 1621164-74-6
Camlipixant (BLU-5937) is an orally active purine P2X3 receptor antagonist that is potent, selective and competitive.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 227 | In Stock |
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| 5MG | 227 | In Stock |
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| 10MG | 370 | In Stock |
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| 25MG | 701 | In Stock |
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| 50MG | 1070 | In Stock |
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| 100MG | 1442 | In Stock |
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| 200MG | Get Quote | In Stock |
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| 500MG | Get Quote | In Stock |
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| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameCamlipixant
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NoteResearch use only, not for human use.
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Brief DescriptionCamlipixant (BLU-5937) is an orally active purine P2X3 receptor antagonist that is potent, selective and competitive.
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DescriptionCamlipixant (BLU-5937) a potent, selective, non-competitive and orally active P2X3 homotrimeric receptor antagonist with an IC50 of 25 nM against hP2X3 homotrimeric. Camlipixant shows potent anti-tussive effect and no taste alteration. Camlipixant can be used for the research of unexplained, refractory chronic cough.
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In Vitro——
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In VivoAnimal Model:Male Dunkin Hartley guinea pigsDosage:0.3, 3, 30 mg/kg Administration:PO, approximately 2 h prior to tussive agent exposure Result:Significantly reduced the histamine-induced enhancement in the number of citric acid-induced coughs. Reduced significantly and dose-dependently the ATP-induced enhancement of citric acid-induced coughs.
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Synonyms——
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PathwayMembrane Transporter/Ion Channel
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TargetP2X Receptor
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RecptorP2X Receptor
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Research Area——
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Indication——
Chemical Information
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CAS Number1621164-74-6
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Formula Weight458.46
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Molecular FormulaC23H24F2N4O4
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 100 mg/mL (218.12 mM; Ultrasonic ) DMSO : 100 mg/mL (218.12 mM; ultrasonic and adjust pH to 3 with 1M HCl )
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SMILESC(C1=C(N=C2N1C=CC(C)=C2)C3=C(F)C=C(C(NC)=O)C=C3F)[C@H]4CN(C(OC)=O)CCO4
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Garceau D, Chauret N. BLU-5937: A selective P2X3 antagonist with potent anti-tussive effect and no taste alteration. Pulm Pharmacol Ther. 2019 Jun;56:56-62.?
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