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A 438079
CAS No. 899507-36-9
A 438079( —— )
Catalog No. M26041 CAS No. 899507-36-9
A 438079 is a potent, and selective antagonist of P2X7 receptor (pIC50: 6.9).
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 85 | In Stock |
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| 2MG | 39 | In Stock |
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| 5MG | 63 | In Stock |
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| 10MG | 93 | In Stock |
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| 25MG | 180 | In Stock |
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| 50MG | 291 | In Stock |
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| 100MG | 516 | In Stock |
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| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameA 438079
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NoteResearch use only, not for human use.
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Brief DescriptionA 438079 is a potent, and selective antagonist of P2X7 receptor (pIC50: 6.9).
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DescriptionA 438079 is a potent, and selective antagonist of P2X7 receptor (pIC50: 6.9).(In Vitro):A 438079 blocks BzATP-(10 μM) evoked changes in intracellular calcium concentrations with an IC50 of 321 nM in 1321N1 cells stably expressing rat P2X7 receptors. A 438079 is also selective for the P2X7 receptor, at concentrations up to 100 μM.(In Vivo):In neuropathic rats noxious and innocuous evoked activity of different classes of spinal neurons is reduced by A 438079 (80 μmol/kg, i.v.), and it significantly raises withdrawal thresh-olds in both the SNL and CCI models. A 438079 has superior neuroprotective effects compared with an equal dose of phenobarbital (25 mg/kg). A 438079 partially but significantly prevents the 6-OHDA-induced depletion of striatal DA stores. Pretreatment with A 438079 reduces nociceptive behavior scores in the HC model.
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In VitroIn 1321N1 cells stably expressing rat P2X7?receptors, A 438079 blocks BzATP-(10 μM) evoked changes in intracellular calcium concentrations with an IC50 of 321 nM. A 438079 is also selective for the P2X7 receptor, at concentrations up to 100 μM.
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In VivoA 438079 (80 μmol/kg, i.v.) reduces noxious and innocuous evoked activity of different classes of spinal neurons in neuropathic rats. A 438079 (100 and 300 μmol/kg, i.p.) significantly raises withdrawal thresh-olds in both the SNL and CCI models. Intraperitoneal injection of A 438079 (5 and 15 mg/kg) 60 min after triggering seizures reduces seizure severity and neuronal death within the hippocampus. A 438079 has superior neuroprotective effects compared with an equally dose of phenobarbital (25 mg/kg).?A 438079 partially but significantly prevents the 6-OHDA-induced depletion of striatal DA stores. Pretreatment with A 438079 reduces nociceptive behaviour scores in the HC model.
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Synonyms——
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PathwayMembrane Transporter/Ion Channel
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TargetP2X Receptor
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RecptorTRPM4
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Research Area——
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Indication——
Chemical Information
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CAS Number899507-36-9
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Formula Weight306.15
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Molecular FormulaC13H9Cl2N5
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 100 mg/mL (326.64 mM)
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SMILESClc1cccc(-c2nnnn2Cc2cccnc2)c1Cl
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.9-Phenanthrol inhibits human TRPM4 but not TRPM5 cationic channels[J]. British Journal of Pharmacology, 2010, 153(8):1697-1705.
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