AZD-9056( AZD9056 )

Catalog No. M14180 CAS No. 345304-65-6

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

Get Quotation Bulk Inquiry Add to Cart

Product Name

AZD-9056
Note

Research use only, not for human use.
Brief Description

A potent, selective, orally bioavailable P2X7 receptor antagonist; inhibits release of pro-inflammatory mediators from isolated human peripheral monocytes (IL-1β and IL-18) and human alveolar macrophages (IL-1β) with IC50 values of 10-13 nM.
Description

A potent, selective, orally bioavailable P2X7 receptor antagonist; inhibits release of pro-inflammatory mediators from isolated human peripheral monocytes (IL-1β and IL-18) and human alveolar macrophages (IL-1β) with IC50 values of 10-13 nM; displays >100-fold selectivity and specificity other P2X receptors; also is an inhibitor of BCRP and weakly inhibited BCRP-mediated transport of methotrexate (IC50=92 uM); significantly reduces disease severity in the streptococcal cell wall (SCW) model of arthritis.Rheumatoid Arthritis Phase 2 Clinical.
In Vitro

——
In Vivo

——
Synonyms

AZD9056
Pathway

Membrane Transporter/Ion Channel
Target

P2X Receptor
Recptor

P2X Receptor
Research Area

Inflammation/Immunology
Indication

Rheumatoid Arthritis

CAS Number

345304-65-6
Formula Weight

419.006
Molecular Formula

C24H35ClN2O2
Purity

>98% (HPLC)
Solubility

——
SMILES

C1C2CC3CC1CC(C2)(C3)CNC(=O)C4=C(C=CC(=C4)CCCNCCCO)Cl
Chemical Name

N-(adamantan-1-ylmethyl)-2-chloro-5-(3-((3-hydroxypropyl)amino)propyl)benzamide

1. Hu H, et al. Int J Mol Med. 2016 Dec;38(6):1922-1932. 2. Seeland S, et al. Int J Mol Med. 2016 Dec;38(6):1922-1932.

Calculator

molnova catalog