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USP8-IN-2
CAS No. 2477651-11-7
USP8-IN-2( —— )
Catalog No. M36043 CAS No. 2477651-11-7
USP8-IN-2 is a potent inhibitor of the deubiquitinating enzymes USP7 and USP8, with an IC50 of 4.0 μM against USP8D. USP8-IN-2 is a potential compound for the treatment of cancer and viral infections.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 245 | In Stock |
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| 5MG | 211 | In Stock |
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| 10MG | 330 | In Stock |
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| 25MG | 548 | In Stock |
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| 50MG | 765 | In Stock |
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| 100MG | 1014 | In Stock |
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| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameUSP8-IN-2
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NoteResearch use only, not for human use.
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Brief DescriptionUSP8-IN-2 is a potent inhibitor of the deubiquitinating enzymes USP7 and USP8, with an IC50 of 4.0 μM against USP8D. USP8-IN-2 is a potential compound for the treatment of cancer and viral infections.
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DescriptionUSP8-IN-2 (Compd U52) is a deubiquitinase USP8 inhibitor with an IC50 value of 6.0 μM. USP8-IN-2 also inhibits the proliferation of H1957 cells with an GI50 value of 24.93 μM, respectively.
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In Vitro——
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In Vivo——
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Synonyms——
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PathwayProteasome/Ubiquitin
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TargetDUB
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RecptorDUB
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Research Area——
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Indication——
Chemical Information
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CAS Number2477651-11-7
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Formula Weight444.9
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Molecular FormulaC19H20ClF3N4OS
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Purity>98% (HPLC)
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Solubility——
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SMILESC(F)(F)(F)C1=NC(=CC=C1)N2CCC(NC(NC3=C(OC)C=CC(Cl)=C3)=S)CC2
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Li zhiyun, et al. Preparing method and application of USP8 inhibitor: China, CN111138358 A. 2020-05-12.
molnova catalog
related products
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USP8-IN-1
USP8-IN-1 is an inhibitor of USP8 with an IC 50 of 1.9 μM. USP8-IN-1 inhibits H1975 cell growth with a GI 50 of 82.04 μM .
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USP10-IN-9
USP10-IN-9 is a HBX19818 analog, selective USP10 inhibitor with IC50 similar to HBX19818.
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C527
C527 is a is a pan DUB enzyme inhibitor. Which has a high potency for the USP1/UAF1 complex (IC50=0.88 μM).
