FT-827( FT827 | FT 827 )

Catalog No. M13071 CAS No. 1959537-86-0

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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Product Name

FT-827
Note

Research use only, not for human use.
Brief Description

A novel potent, specific, covalent USP7 inhibitor with Kd of 7.8 uM (USP7 catalytic domain).
Description

A novel potent, specific, covalent USP7 inhibitor with Kd of 7.8 uM (USP7 catalytic domain); modifies the catalytic Cys223 of USP7 and inhibits the enzyme with kinact/Ki of 66 M-1s-1, display good USP7 selectivity in a panel of 38 deubiquitinases (DUBs).
In Vitro

——
In Vivo

——
Synonyms

FT827 | FT 827
Pathway

Proteasome/Ubiquitin
Target

DUB
Recptor

DUB
Research Area

Cancer
Indication

——

CAS Number

1959537-86-0
Formula Weight

548.618
Molecular Formula

C27H28N6O5S
Purity

>98% (HPLC)
Solubility

DMSO : 125 mg/mL 227.85 mM
SMILES

O=C(N1CCC(O)(CN2C=NC(N(C)N=C3)=C3C2=O)CC1)C(C=C4)=CC=C4C5=CC=CC=C5NS(C=C)(=O)=O
Chemical Name

N-(4'-(4-hydroxy-4-((1-methyl-4-oxo-1,4-dihydro-5H-pyrazolo[3,4-d]pyrimidin-5-yl)methyl)piperidine-1-carbonyl)-[1,1'-biphenyl]-2-yl)ethenesulfonamide

1. Turnbull AP, et al. Nature. 2017 Oct 26;550(7677):481-486.

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