Cart
sales@molnova.com
KL001
CAS No. 309928-48-1
KL001( KL-001 | KL 001 )
Catalog No. M13992 CAS No. 309928-48-1
KL001 (KL-001) is a small molecule that specifically interacts with cryptochrome (CRY) and small molecule modulator of the circadian clock.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 85 | In Stock |
|
| 5MG | 76 | In Stock |
|
| 10MG | 110 | In Stock |
|
| 25MG | 188 | In Stock |
|
| 50MG | 272 | In Stock |
|
| 100MG | 407 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | 914 | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
-
Product NameKL001
-
NoteResearch use only, not for human use.
-
Brief DescriptionKL001 (KL-001) is a small molecule that specifically interacts with cryptochrome (CRY) and small molecule modulator of the circadian clock.
-
DescriptionKL001 (KL-001) is a small molecule that specifically interacts with cryptochrome (CRY) and small molecule modulator of the circadian clock; prevents SCFFBXL3-mediated ubiquitination and degradation of CRY, resulting in lengthening of the circadian period, interacts directly with CRY1 and CRY2 and stabilizes CRY proteins; KL001-mediated CRY stabilization inhibited glucagon-induced gluconeogenesis in primary hepatocytes; KL001 is the first-in-class cryptochrome-targeting circadian modulator and substrate-targeting ubiquitination antagonist.
-
In Vitro——
-
In Vivo——
-
SynonymsKL-001 | KL 001
-
PathwayProteasome/Ubiquitin
-
TargetDUB
-
RecptorDUB
-
Research Area——
-
Indication——
Chemical Information
-
CAS Number309928-48-1
-
Formula Weight398.477
-
Molecular FormulaC21H22N2O4S
-
Purity>98% (HPLC)
-
SolubilityIn Vitro:?DMSO : 5 mg/mL (12.55 mM助)
-
SMILESCS(=O)(N(CC(O)CN1C2=C(C3=C1C=CC=C3)C=CC=C2)CC4=CC=CO4)=O
-
Chemical NameN-[3-(9H-Carbazol-9-yl)-2-hydroxypropyl]-N-(2-furanylmethyl)-methanesulfonamide
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1. Hirota T, et al. Science. 2012 Aug 31;337(6098):1094-7.
2. Nangle S, et al. Cell Res. 2013 Dec;23(12):1417-9.
3. St John PC, et al. Proc Natl Acad Sci U S A. 2014 Feb 4;111(5):2040-5.
4. Oshima T, et al. Angew Chem Int Ed Engl. 2015 Jun 8;54(24):7193-7.
molnova catalog
related products
-
P22074
P22074 is a USP7 inhibitor. It is not an active antagonist like its halogenated related compounds. p22074 has antitumour activity.
-
MF-094
MF-094 (MF094) is a potent, highly selective inhibitor of ubiquitin specific protease 30 (USP30) with IC50 of 0.12 uM.
-
Vialinin A
Vialinin A (Terrestrin A), a p-terphenyl compound, exhibits antioxidant properties and acts as a potent inhibitor of TNF-α, USP4, USP5, and sentrin/SUMO-specific protease 1 (SENP1).
