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KL001
CAS No. 309928-48-1
KL001( KL-001 | KL 001 )
Catalog No. M13992 CAS No. 309928-48-1
KL001 (KL-001) is a small molecule that specifically interacts with cryptochrome (CRY) and small molecule modulator of the circadian clock.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 85 | In Stock |
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| 5MG | 76 | In Stock |
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| 10MG | 110 | In Stock |
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| 25MG | 188 | In Stock |
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| 50MG | 272 | In Stock |
|
| 100MG | 407 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | 914 | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameKL001
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NoteResearch use only, not for human use.
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Brief DescriptionKL001 (KL-001) is a small molecule that specifically interacts with cryptochrome (CRY) and small molecule modulator of the circadian clock.
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DescriptionKL001 (KL-001) is a small molecule that specifically interacts with cryptochrome (CRY) and small molecule modulator of the circadian clock; prevents SCFFBXL3-mediated ubiquitination and degradation of CRY, resulting in lengthening of the circadian period, interacts directly with CRY1 and CRY2 and stabilizes CRY proteins; KL001-mediated CRY stabilization inhibited glucagon-induced gluconeogenesis in primary hepatocytes; KL001 is the first-in-class cryptochrome-targeting circadian modulator and substrate-targeting ubiquitination antagonist.
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In Vitro——
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In Vivo——
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SynonymsKL-001 | KL 001
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PathwayProteasome/Ubiquitin
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TargetDUB
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RecptorDUB
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Research Area——
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Indication——
Chemical Information
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CAS Number309928-48-1
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Formula Weight398.477
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Molecular FormulaC21H22N2O4S
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 5 mg/mL (12.55 mM助)
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SMILESCS(=O)(N(CC(O)CN1C2=C(C3=C1C=CC=C3)C=CC=C2)CC4=CC=CO4)=O
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Chemical NameN-[3-(9H-Carbazol-9-yl)-2-hydroxypropyl]-N-(2-furanylmethyl)-methanesulfonamide
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Hirota T, et al. Science. 2012 Aug 31;337(6098):1094-7.
2. Nangle S, et al. Cell Res. 2013 Dec;23(12):1417-9.
3. St John PC, et al. Proc Natl Acad Sci U S A. 2014 Feb 4;111(5):2040-5.
4. Oshima T, et al. Angew Chem Int Ed Engl. 2015 Jun 8;54(24):7193-7.
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