USP28-IN-4

Research use only, not for human use.

USP28-IN-4 is a potent USP28 inhibitor with an IC50 value of 0.04 μM against USP28. USP28-IN-4 exhibits anticancer activity and inhibits USP2, USP7, USP8, USP9x, UCHL3 and UCHL5.

USP28-IN-4 is a USP28 inhibitor (IC50=0.04 μM) with high selectivity over USP2, USP7, USP8, USP9x, UCHL3 and UCHL5. USP28-IN-4 shows cytotoxicity against cancer cells, down-regulates the cellular level of c-Myc through ubiquitin-proteasome system. USP28-IN-4 also decreases the ankyrase-1/2 level in vitro. USP28-IN-4 enhance the sensitivity of colorectal cancer cells to Regorafenib (HY-10331).

Western Blot Analysis Cell Line:Human colorectal cancer cells HCT116 and Ls174T Concentration:20 μM, 30 μM, 50 μM, and 60 μM, for Ls174T; 30 μM, 50 μM, 60 μM and 80 μM for HCT116 Incubation Time:24 h Result:Dose-dependently down-regulated the cellular level of c-Myc.

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Proteasome/Ubiquitin

DUB

DUB

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2931509-15-6

461.36

C22H18Cl2N2O3S

>98% (HPLC)

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O=C(NC1=CC=C(Cl)C(=C1)C=2C=CC3=C(C2)CNC3)C4=CC=C(C=C4Cl)S(=O)(=O)C

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(-20℃)

With Ice Pack

≥ 2 years