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USP8-IN-3
CAS No. 2477651-10-6
USP8-IN-3( —— )
Catalog No. M36040 CAS No. 2477651-10-6
USP8-IN-3 is a potent inhibitor of the deubiquitinating enzymes USP7 and USP8, with IC50 of 4.0 μM against USP8D.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 46 | In Stock |
|
| 5MG | 55 | In Stock |
|
| 10MG | 93 | In Stock |
|
| 25MG | 200 | In Stock |
|
| 50MG | 318 | In Stock |
|
| 100MG | 449 | In Stock |
|
| 500MG | 888 | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameUSP8-IN-3
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NoteResearch use only, not for human use.
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Brief DescriptionUSP8-IN-3 is a potent inhibitor of the deubiquitinating enzymes USP7 and USP8, with IC50 of 4.0 μM against USP8D.
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DescriptionUSP8-IN-3 (Compd U51) is a deubiquitinase USP8 inhibitor with an IC50 value of 4.0 μM. USP8-IN-3 also inhibits the proliferation of GH3 and H1957 cells with GI50s of 37.03 μM and 6.01 μM, respectively.
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In VitroWestern Blot Analysis Cell Line:/Concentration:6.25 μM, 12.5 μM, 25 μM, 50 μM, and 100 μM Incubation Time:15 min; added Di-Ub substrate for another 1 h Result:Decreased the cleaved diubiquitin level.
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In Vivo——
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Synonyms——
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PathwayProteasome/Ubiquitin
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TargetDUB
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RecptorDUB
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Research Area——
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Indication——
Chemical Information
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CAS Number2477651-10-6
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Formula Weight425.43
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Molecular FormulaC18H18F3N5O2S
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 100 mg/mL (235.06 mM; Ultrasonic )
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SMILESC(F)(F)(F)C1=NC(=CC=C1)N2CCC(NC(NC3=CC=C(N(=O)=O)C=C3)=S)CC2
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Li zhiyun, et al. Preparing method and application of USP8 inhibitor: China, CN111138358 A. 2020-05-12.
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