Wu-5

Research use only, not for human use.

Wu-5 is a potent USP10 inhibitor that inhibits FLT3 and AMPK pathways, promoting the breakdown of FLT3-ITD and inducing apoptosis.

Wu-5 is a USP10 inhibitor that can inhibit FLT3 and AMPK pathways, induce FLT3-ITD degradation and induce apoptosis.

Cell Viability Assay Cell Line:U937, HL60, MV4-11, Molm13, and MV4-11-R cells Concentration:10 μM Incubation Time:24, 48, 72 h Result:Significantly inhibited the growth of the FLT3-ITD-positive cells (MV4-11, MV4-11-R and Molm13 cells), but had no or little effect on the proliferation of the FLT3-ITD negative cells (U937 and HL60 cells).Apoptosis Analysis Cell Line:MV4-11, and Molm13 cells Concentration:1, 2.5, 5 μM Incubation Time:24, 48 h Result:Induced the apoptosis of MV4-11 and Molm13 in a concentration and time-dependent manner.Western Blot Analysis Cell Line:MV4-11, MV4-11-R, and Molm13 cells Concentration:5 μM Incubation Time:24 h Result:Induced FLT3-ITD degradation.

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Proteasome/Ubiquitin

DUB

DUB

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2630378-05-9

351.33

C15H13NO7S

>98% (HPLC)

In Vitro:?DMSO : 25 mg/mL (71.16 mM; Ultrasonic (<60°C)

O=C(C1=CC=C(C=C1)OC2=C([N+]([O-])=O)C=C(C(OCC)=O)S2)OC

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(-20℃)

With Ice Pack

≥ 2 years